Surgery – Means for introducing or removing material from body for... – Infrared – visible light – ultraviolet – x-ray or electrical...
Patent
1999-07-08
2000-05-16
Coggins, Wynn Wood
Surgery
Means for introducing or removing material from body for...
Infrared, visible light, ultraviolet, x-ray or electrical...
A61N 130
Patent
active
060649089
DESCRIPTION:
BRIEF SUMMARY
The invention relates to an iontophoresis device for transcutaneous administration of active principles to a subject, which device comprises at least one electrode assembly equipped with a membrane. It furthermore concerns the said electrode assembly.
In the current treatment of numerous conditions, it is necessary to administer a medication or other active principle to a subject in a controlled and often prolonged manner. Amongst the numerous techniques available to the formulation pharmacist, that of iontophoresis represents an advantageous alternative for controlling the administration of active principles such as medicinal substances into the subject's body. One such technique consists in using an electric current for controlling the quantity and also the speed of delivery of an active principle through a subject's skin. In numerous cases, this technique proves highly effective by significantly increasing the supply of active principle due to the current, in comparison to the quantity delivered without a current.
The transcutaneous administration of an active principle by iontophoresis to a subject is generally performed, starting with an aqueous solution or aqueous gel containing the active principle in an at least partially ionized form or in a neutral form, by applying an electric signal between, on the one hand, a first electrode called the active electrode, having the same polarity as the ions of the active principle to be administered or a positive polarity if the active principle is neutral, and being in contact with a reservoir element, which contains the active principle and is placed in contact with a first area of the subject's skin, and, on the other hand, a second electrode called the back electrode or passive electrode, of opposite polarity to that associated with the active principle, which is placed, directly or via an arbitrary electrolyte, in contact with a second area of the subject's skin which is separate from the first area. During the flow of current generated by applying a voltage between the electrodes, in the circuit thus produced, the ions of the active principle migrate away from the electrode of the same polarity (active electrode), through the subject's skin and tissues towards the electrode of opposite polarity (back electrode) and thus find themselves passing through the subject's circulatory system. In the same way, the active principle neutral molecules are entrained, away from the positive electrode, in the aqueous electroosmotic flux through the subject's skin and tissues towards the negative electrode (back electrode) and thus find themselves passing through the subject's circulatory system.
One iontophoresis device for transcutaneous administration of an active principle to a subject is of the type comprising a first electrode assembly consisting of a first electrode called the active electrode, in contact with an active reservoir element, designed, on the one hand, to contain an electrolyte containing the active principle in an at least partially ionized form or in a neutral form and, on the other hand, in order to ensure, when it is placed in contact with an area of the subject's skin, ionically conducting continuity between the said first electrode and the said area, a second electrode assembly consisting either (i) of a second electrode, called the back electrode, or preferably (ii) of a second electrode of this type in contact with a reservoir element designed to contain an electrolyte and to ensure, when it is placed in contact with a portion of the subject's skin, ionically conducting continuity between the second electrode and the said portion and an electric signal generator which can be connected to each of the said first and second electrodes in such a way that the first electrode has the same polarity as the ions of the active principle or a positive polarity if the said active principle is neutral and that the second electrode has a polarity opposite to that of the first electrode.
Citation WO-A-9116943 relates to an iontophoresis device containing at
Barbier Alain
Muller Daniel
Perie Frederic
Coggins Wynn Wood
Elf Aquitaine
Mendez Manuel
Sanofi
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