Device for incorporation and release of biologically active agen

Details Device for incorporation and release of biologically active agen Device for incorporation and release of biologically active agen

1999-04-23

2000-10-24

Beck, Shrive

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Implantable permanent prosthesis

427 226, 427 229, 427309, A61K 2700, B05D 312

Patent

active

061363693

ABSTRACT:
The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipis, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprepitation of the biologically active substance.

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patent: 4847163 (1989-07-01), Shimamune et al.
patent: 5205921 (1993-04-01), Shirkanzadeh
patent: 5478237 (1995-12-01), Ishizawa
patent: 5603338 (1997-02-01), Beaty
patent: 5947893 (1999-09-01), Agrawal et al.

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