Device for incorporation and release of biologically active agen

Details Device for incorporation and release of biologically active agen Device for incorporation and release of biologically active agen

1997-07-03

2000-11-07

Prebilic, Paul B.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

623 16, 4332011, A61F 202

Patent

active

061439487

ABSTRACT:
The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipids, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprecipitation of the biologically active substance.

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