Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1995-03-10
1997-10-21
Rimell, Sam
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604207, 604208, A61M 500
Patent
active
056791119
DESCRIPTION:
BRIEF SUMMARY
DESCRIPTION
1. Technical Field
The present invention is directed to a device for dosing and administering a liquid preparation. More specifically, the invention refers to repeated dosing and administering of liquid pharmaceutic preparations by parenteral injection from a multi-dose container. Still more specifically, the invention refers to a device for infinitely variable dosing and administering of liquid pharmaceutic preparation by parenteral injection from a multi-dose container, such as an injection cartridge.
2. Background Art
International patent application PCT/SE92/00654 describes a method for repeated dosing of a liquid preparation of a pharmaceutically active agent by administration from a multi-dose container having a defined volume. What characterizes this method is that the amount of the preparation to be dosed is selected to be 1/N of the volume of the multi-dose container, N being an integer having a value of 2 or higher. The value of N is selected and set before the repeated dosing of the preparation from the multi-dose container is started, and is maintained unchanged through a series of N successive administrations from the multi-dose container, which has consequently then been emptied. As a second variable or degree of freedom is used the concentration of the liquid preparation, such that the portion 1/N will give the desired dose of the pharmaceutically active agent. By using a series of containers with preparations of different concentrations, and a plurality of values for N, it is clear that a great number of different doses of the active agent can be obtained.
Through the method and system described, it has thus become possible to administer a number of doses of a liquid preparation from a multi-dose container in such a way that essentially no residue of the preparation is obtained. This is of considerable importance when very expensive pharmaceutical agents are to be administered, such as growth hormones.
The above-mentioned international application PCT/SE92/00654 also discloses a device for the repeated dosing of a liquid preparation from a multi-dose container. Such a device comprises a holder device for a multi-dose container having a defined volume and containing a preparation having a defined composition, and the multi-dose container is provided with a fixed front wall, through which may be arranged an outlet for the preparation, and a movable rear wall, which may act as a piston for expelling the preparation through said outlet, and a piston rod, by which the rear movable wall may be urged forwards. What characterizes the device is that the piston rod is provided with releasable blocking means by which the forward movement of it is limited to a predetermined length, which corresponds to a forward movement of the rear movable wall corresponding to 1/N of the multi-dose container, N being an integer having a value of 2 or higher.
It is to be noted that in the following specification and claims, the expressions "front" and "forward" refer to the direction in which the liquid preparation is made to flow when it is administered. Conversely, the opposite direction is denoted as "rear" and "rearward", respectively.
In a preferred embodiment of the device described above, it comprises a barrel for holding at its front end part an injection cartridge and a piston rod for actuating said injection cartridge to expel a set amount of the liquid preparation from the cartridge. The releasable blocking means comprise a fixed chuck and a movable chuck which clamp around the piston rod through the action of a spring force, said clamping action being releasable by reducing said spring force. Thus, the front chuck is fixed in relation to the barrel and the cartridge, and its clamping action around the piston rod may be actuated to lock it securely to the chuck, or may be released to allow the piston rod to move in relation to the chuck. The rear chuck is movable in relation to the barrel and the cartridge, and can be moved along the piston rod, when its clamping action is released, or may foll
REFERENCES:
patent: 2413303 (1946-01-01), Folkman
patent: 4865591 (1989-09-01), Sams
patent: 5279585 (1994-01-01), Balkwill
patent: 5304152 (1994-04-01), Sams
DE Leeuw Jan
Hjertman Birger
Pharmacia & Upjohn Aktiebolag
Rimell Sam
Yeh Luke
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