Device for discrimination of fluorescence lifetimes and uses...

Details Device for discrimination of fluorescence lifetimes and uses... Device for discrimination of fluorescence lifetimes and uses...

2006-05-09

2006-05-09

Gagliardi, Albert (Department: 2884)

Radiant energy

Luminophor irradiation

C250S459100

Reexamination Certificate

active

07041986

ABSTRACT:
The present invention provides methods for determining fluorescence lifetime of a fluorophor or an optical sensor using frequency domain gated detection. The method comprises the steps of exciting the fluorophor with frequency modulated light from a pulsed light source, gating a photodetector during excitation of the fluorophore, detecting light emitted from the fluorophor with the photodetector, where the emission light exhibits a phase shift in frequency from that of the excitation light, converting the detected excitation light to an amplified electric signal, and evaluating the amplified electric signal as a measure of fluorescence lifetime of the fluorophor. Also provided is a device with which to use the methods disclosed herein.

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