Device for determining concentration-dependent electrophysiologi

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Sample mechanical transport means in or for automated...

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422 63, 422 67, 422 681, 422 8202, 435291, G01N 3502, G01N 2731

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active

054494923

ABSTRACT:
The determination of concentration-dependent parameters in a series of measurements, in particular for the determination of dose-effect correlations, the solutions to be developed are each contained in chambers positioned on a round tray in radial symmetrically arrangement. The respective chamber just to be determined is moved underneath the measuring device via a gyratory movement of a round tray controlled by a computer and the vertical disk between the measuring device at the chamber to be measured is also lowered by computerized control so far until the measuring device dives into the solution in the chamber. The device to realize the process comprises a horizontally rotatable round tray as well as a lifting device wherewith either the total round tray including all chambers positioned thereupon can be vertically moved or only that chamber being immediately positioned underneath the measuring device. The measuring device is composed of a measuring cell comprising a suction tube in which the solution to be measured is sucked and a measuring system projecting into said tube. In particular, the process and the device are suited to measure series of concentrations where a reactant, in particular a bioindicator, constantly loses activity in a run of a series of measurements.

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Criado et al., "A membrane Fusion Strategy for Single-Channel Recordings of Membranes Usually Non-Accessible to Patch-Clamp Pipette," FEBS Letters 05296, vol. 224 (1), Nov. 1987, 172-76.
Hamill et al., "Improved Patch-Clamp Techniques for High-Resolution Current Recording from Cells and Cell-Free Membrane Patches", Pflugers Archiv., (1981) 391 85-100.

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