Chemistry: analytical and immunological testing – Involving diffusion or migration of antigen or antibody
Patent
1996-10-28
1999-03-02
Spiegel, Carol A.
Chemistry: analytical and immunological testing
Involving diffusion or migration of antigen or antibody
435 79, 435 792, 435 794, 435967, 435969, 436518, 436525, 436530, 436810, 436825, 53038824, G01N 33558
Patent
active
058770291
ABSTRACT:
Antibodies having binding affinity for free IGFBP-1, biological compositions including antibodies having binding affinity for free IGFBP-1, kits for detecting free IGFBP-1 using the antibodies, and cell lines for producing the antibodies are provided. Also provided are devices and methods for detecting free IGFBP-1 and a rupture in a fetal membrane based on the presence of amniotic fluid in a vaginal secretion, as indicated by the presence of free IGFBP-1 in the vaginal secretion. The antibodies that are provided may be characterized by their ability to selectively recognize those IGFBP-1 molecules which are free of IGF-1 and IGF-2, i.e., antibodies which have a binding affinity for free IGFBP-1 that is greater than a binding affinity of the antibody to bound IGFBP-1. These antibodies may also be characterized by their competition with IGF-1 and IGF-2 for binding to IGFBP-1.
REFERENCES:
patent: 4235601 (1980-11-01), Deutsch et al.
patent: 4743542 (1988-05-01), Graham, Jr. et al.
patent: 4788138 (1988-11-01), Tung et al.
patent: 4861711 (1989-08-01), Friesen et al.
patent: 4981786 (1991-01-01), Dafforn et al.
patent: 5006474 (1991-04-01), Horstman et al.
patent: 5120643 (1992-06-01), Ching et al.
patent: 5308775 (1994-05-01), Donovan et al.
Brewer et al. "Cloning, Characterization, and Expression of a Human Insulin-Like Growth Factor Binding Protein," Biochem Biophys Res Comm 152:1289-1297, 1988.
Khosravi et al., "Immunoassay of insulin-like growth factor binding protein-1," Clin. Chem. 43(3):523-532, 1997.
Medix Biochemica 1988 Monoclonal Antibodies Catalog pp. 14-16, 18, 1988.
Wang et al., "Purification and assay of insulin-like growth factor binding protein-1 . . . " J. of Endocrinol. 128:161-168, 1991.
Westwood et al., "The Phosphorylation Pattern of Insulin-like Growth Factor-Binding Protein-1 . . . ," J. of Clin. Endocrin. Metabol. 79:1735-1741, 1994.
Bell, S.C., et al., "Monoclonal Antibodies to Human Secretory `Pregnancy-Associated Endometrial .alpha..sub.1 -Globulin,` An Insulin-Like Growth Factor Binding Protein: Characterization and Use in Raidoimmunoassay, Western Blots, and Immunohistochemistry", AJRI (American Journal of Reproductive Immunology) 20:3:87-96 (Jul. 1989).
Bell, S.C., et al., "N-terminal Amino Acid Sequence of Human Pregnancy-associated Endometrial .alpha..sub.1 -Gobulin, an Endometrial Insulin-like Growth Factor (IGF) Binding Protein--Evidence for Two Small Molecular Weight IGF Binding Proteins, Endocrinology", (1988) vol. 123, pp. 1202 to 1204.
Bohn, H., et al., "Insolation and Charcterization of a New Placenta Specific Protein (PP.sub.12)", Arch. Gynecol 229, 279-291 (1980). In German with English Abstract.
Boltovskaya, et al., "Histochemical and Clinico-Diagnostiocal Study of the Placental Alpha-1-Microgobullin (PAMG-1) Using Monocolonal Antibodies", Bulletin of Experimental Biology and Medicine, USSR, Nr. 7, 1991, pp. 397-400. In Russian with English Abstract.
Friedman, M. L., et al., "Diagnosis of Ruptured Fetal Membranes", Am. J. Obst. & Gynec, Jun. 1969, pp. 544-550.
Hellemans, P., et al., "Preliminary Results with the Use of the ROM-check Immunoassay in the Early Detection of Rupture of the Amniotic Membranes", Eur. J. Ob. & Gyn and Repro. Biol. 43 (1992) 173-179.
Hodgkinson, S. C., et al., "Metabolic Clearance Rate of Insulin-like Growth Factor-1 in Fed and Starved Sheep", J. Endroc. (1987) 115,233-240.
Jones, John I., et al., "Insulin-Like growth Factors and Their Binding Proteins: Biological Actions", Endocrine Reviews, 1995, pp. 3-34.
Keirse, M. J. N. C., et al., 43. "Prelabour Rupture of the Membranes Preterm, Effective Care In Pregnancy and Childbirth", Oxford U. Press, 1989, pp. 666-693.
Koistinen, R., et al., "Placental Protein 12 is a Decidual Protein that Binds Somatomedin and Has an Identical N-Terminal Amino Acid Sequence with Somatomedin-Binding Protein from Human Amniotic Fluid", Endorinology, 118: 1375-1378 (1986).
Koninckx, P.R., et al., "Prolactin Concentration in Vaginal Fluid: A New Method for Diagnosing Ruptured Membranes", Brit. J. Ob. & Gyn., Jun. 1981, 88:607-610.
Lockwood, C.J., et al., "Fetal Fibronectin in Cervical and Vaginal Secretions as a Predictor of Preterm Delivery", N.E.J. Med, 1991 Sep. 5, pp. 669-674.
Lockwood, C.J., et al., "Fetal Membrane Rupture is Associated with the Presence of Insulin-like Growth Factor-Binding Protein-1 in Vaginal Secretions", Am. J. Obstet. Gynecol., 171(1): 146-150 (Jul. 1994).
Pekonen, F., et al., "A Monoclonal Antibody-base Immunoradiometric Assay for Low Molecular Weight Insulin-like Growth Factor Binding Protein/Placental Pretein 12.", J. Immunoassay, 10(4), 325-337 (1989).
Povoa, G., et al., "Cross-reaction of Serum Somatomedin-binding Protein in a Radioimmunoassay Developed for Somatomedin-binding Protein Isolated from Human Amniotic Fluid", Acta Endrocrinologica 1984, 107:563-570.
Rochelson, B.L., et al., "A Rapid Colorimetric AFP Monoclonal Antibody Test for the Diagnosis of Preterm Rupture of the Membranes", Ob. and Gyn. 69:163-165 (Feb. 1987).
Rochelson, B.L., et al., "Rapid Assay--Possible Application in the Diagnoisis of Premature Rupture of the Membranes", Ob. and Gyn. 62:414-418 (Oct. 1983).
Roghani, M., et al., "Two Insulin-like Growth Factor (IGF)--Binding Proteins are Responsible for the Selective Affnity for IGF-II of Cerebrospinal Fluid Binding Proteins", J. Clin. Endro & Metabolism, 73-658-666 (1991).
Rutanen, E., et al., "Measurement of Insulin-like Growth Factor Binding Protein-1 in Cervical/Vaginal Secretions: Comparison with the ROM-check Membrane Immunoassay in the Diagnosis of Ruptured Fetal Membranes", Clinica Chimica Acta 214 (1993) 73-81.
Rutanen, E., et al., "Monoclonal antibodies to the 37-34K Insulin-like Growth Factor Binding Protein", Biochem. and Biophys. Res. Communications 152:1:208-215 (1988).
Smith, R. P., et al., "A Technic for the Detection of Rupture of the Membranes", Obstetrics and Gynecology, pp. 172-176, Aug. 1976.
Waites, G.T., et al., "Human `Pregnancy-associated Endormetrial .alpha..sub.1 -globulin`, an Insulin-like Growth Factor-binding Protein: Immunohistological Localization in the Decidua and Placenta During Pregnancy Employing Monoclonal Antibodies", J. Enmdorcinol. 120;351-357 (1989).
Boltovskaya Marina
Fuks Boris
Konstantinov Alexander
Nazimova Svetlana
Starosvetskaya Nelli
California Research LLC
Spiegel Carol A.
Walker William B.
LandOfFree
Device for detecting free IGFBP-1 does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Device for detecting free IGFBP-1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Device for detecting free IGFBP-1 will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-422174