Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Reexamination Certificate
1999-03-08
2001-11-27
Seidel, Richard K. (Department: 3763)
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
C604S261000, C604S275000, C604S912000
Reexamination Certificate
active
06322542
ABSTRACT:
The present application represents U.S. national stage of international application PCT/SE98/023138 with an international filing date of Dec. 15, 1998, and which was published in English under Article 21(2) of the PCT on Jul. 1, 1999. The international application claims priority to Swedish application 9704769-0, which was filed on Dec. 19, 1997.
FIELD OF THE INVENTION
The present invention relates to a delivery means for and a method of delivering liquid containing medicament to a posterior region of the nasal cavity, in particular the delivery of local anaesthetic in the treatment of vascular headache.
BACKGROUND OF THE INVENTION
U.S. Pat. No. 4886493 discloses an applicator for the delivery of local anaesthetic to the sphenopalatine ganglion, which applicator comprises a flexible tube, one end of which is open and in use located adjacent the sphenopalatine ganglion and through the other end of which a metered volume of local anaesthetic in the form of a spray is passed. This applicator, whilst delivering a metered volume of local anaesthetic to the sphenopalatine ganglion, still, however, does not completely effectively deliver the local anaesthetic.
It is an aim of the present invention to provide a delivery means for delivering medicament more effectively to a posterior, in particular the posterior most, region of the nasal cavity. In this way, more immediate effect will be obtained and the user will be required less often to re-administer medicament to achieve the effect, which over delivery can lead to side effects.
SUMMARY OF THE INVENTION
The present invention provides a delivery means for delivering liquid containing medicament to a posterior region of the nasal cavity, comprising an elongate tubular member and a nozzle at the free end thereof, which nozzle includes at least one opening through which liquid is in use delivered. The delivery means finds particular application in the delivery of local anaesthetic, such as Xylocaine®, for the treatment of vascular headache, especially migraine.
The present invention also extends to a delivery device which incorporates the above-described delivery means.
In one embodiment the delivery device includes a delivery unit for delivering a plurality of metered volumes of liquid containing medicament to the delivery means, which delivery unit comprises a main body including a barrel and a plunger axially movable within the barrel, wherein one of the barrel and the plunger includes at least one path and the other of the barrel and the plunger includes at least one projection which is movable along the at least one path, the at least one path having an axially forward surface, in the direction of movement of the at least one projection through the at least one path in the delivery of liquid, which defines a plurality of axially-spaced steps at which the at least one projection is locatable.
In another embodiment the delivery device includes a delivery unit for delivering one or more metered volumes of liquid containing medicament to the delivery means, which delivery unit comprises a pump assembly on the actuation of which a metered volume of liquid is delivered to an outlet thereof. Preferably, the pump assembly comprises a main body which defines a chamber having a first opening that defines an inlet, a second opening that defines an outlet and a third opening across which a resilient membrane is disposed, delivery of a metered volume of liquid to the outlet being achieved by movement of the membrane.
The present invention further provides a method of delivering liquid containing medicament to a posterior region of the nasal cavity, comprising the steps of inserting a delivery means comprising an elongate tubular member and a nozzle at the free end thereof, which nozzle includes at least one opening, into one of the nasal passages so as to locate the nozzle near a posterior region of the nasal cavity and delivering liquid through the at least one opening in the nozzle.
In preferred embodiments the delivery means and the method of the present invention are used to deliver liquid containing medicament to the pterygopalatine fossa and the surrounding pharyngeal and nasal area delineated by proximally situated so orbitale and distally os maxillaris.
The present invention yet further provides a delivery device for delivering a plurality of metered volumes of liquid containing medicament, comprising a delivery means as an elongate tubular member through which liquid containing medicament is in use delivered and a delivery unit coupled to the delivery means, which delivery unit comprises a main body including a barrel and a plunger axially movable within the barrel, wherein one of the barrel and the plunger includes at least one path and the other of the barrel and the plunger includes at least one projection which is movable along the at least one path, the at least one path having an axially forward surface, in the direction of movement of the at least one projection through the at least one path in the delivery of liquid, which defines a plurality of axially-spaced steps at which the at least one projection is locatable.
The present invention still further provides a delivery device for delivering one or more metered volumes of liquid containing medicament, comprising a delivery means through which liquid containing medicament is in use delivered and a delivery unit coupled to the delivery means, which delivery unit comprises a pump assembly on the actuation of which a metered volume of liquid is delivered to the delivery means and a housing in which the delivery means and the pump assembly are slideably disposed, wherein the delivery means is movable between a first position in which the delivery means is substantially within the housing and a second position in which the delivery means is extended from the housing in a position ready for use.
Preferred embodiments of the present invention will now be described hereinbelow by way of example only with reference to the accompanying drawings, in which:
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The International Search Report for PCT/US98/02318, filed by applicants on Dec. 15, 1998.
Eek Arne
Nilson Billy
Astrazeneca AB
Pillsbury & Winthrop LLP
Sanzo Michael A.
Seidel Richard K.
Sirmons Kevin C.
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