Device for continuous in vivo measurement of blood glucose conce

Details Device for continuous in vivo measurement of blood glucose conce Device for continuous in vivo measurement of blood glucose conce

1986-04-03

1987-08-11

Howell, Kyle L.

Surgery

Truss

Pad

128736, 604 8, 604 50, A61B 500

Patent

active

046854630

ABSTRACT:
A device is disclosed for continuous in vivo measurement of blood glucose concentrations in arterial blood. A quantity of glucose oxidase enzyme is confined within at least one elongate double-lumened tube by means of a semi-permeable membrane tubule permeable to permit diffusion of glucose from blood passing through an inner lumen of the tube into an outer lumen in which the enzyme is confined. The enzyme catalyzes the oxidation of glucose to produce heat. The tube is insulated so that the heat produced by the glucose oxidation is transferred to the blood flowing through the inner lumen. Either micro-thermocouples or solid state temperature sensors are positioned to measure the increase in temperature of the blood to produce a signal that is a function of the glucose concentration in the blood.

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Article entitled "Use of an Enzyme Thermister in Continuous Measurements and Enzyme Reactor Control", by Bengt Danielsson, Bo Mattiasson, Roland Karlsson, and Fredrik Winqvist, Biochemistry 2, Chemical Center, University of Lund, Box 740, S-220 07 Lund 7, Sweden, published in the magazine Biotechnology and Bioengineering, vol. XXI, pp. 1749-1766, (1979)--Accepted for publication Nov. 27, 1978.

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