Device for confining live neural cells cultivated on a chip...

Active solid-state devices (e.g. – transistors – solid-state diode – Responsive to non-electrical signal

Reexamination Certificate

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Details

C257SE29112, C435S305300, C607S115000

Reexamination Certificate

active

07489012

ABSTRACT:
The invention is directed to a microdevice for containing electrically coupled cells while allowing their growth that allows the addition or removal of cells from their containment by providing an actuatable gate. When the gate is actuated, for example with electric current, the cells may be added or removed from their containment. The invention may be applied to a neurochip or any device for growing cells in a defined spatial arrangement.

REFERENCES:
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patent: 6667172 (2003-12-01), Janigro et al.
patent: 6691513 (2004-02-01), Kolesar
patent: 6775048 (2004-08-01), Starkweather et al.
M. Maher, “The Neurochip: a new multielectrode device for stimulating and recording from cultured neurons,” J. of Neuroscience Methods, vol. 87, 1999, p. 45-56.
Wright et al., Towards a Functional MEMS Neurowell by Physiological Experimentation, Technical Digest: ASME 1996 International Mechanical Engineering Congress and Exposition, DSC-vol. 59, Atlanta, GA, pp. 333-338, Nov. 1996.
Zeck et al., Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip, Proc Natl Acad Sci USA 98(18):10457-62, Aug. 2001.
Maher et al., The neurochip: A new multielectrode device for stimulating and recording from cultured neurons, J. Neurosci. Meth. 87:45-56, 1999.

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