Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1987-12-10
1990-07-17
Pellegrino, Stephen C.
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604191, 604238, 604416, 206221, A61M 528
Patent
active
049418769
DESCRIPTION:
BRIEF SUMMARY
The present invention concerns a device for conditioning liquid substances or liquids and solids, comprising a generally cylindrical, elongate ampoule of circular cross-section with two compartments each disposed in the extension of the other and separated by an intermediate moveable elastomeric plug or stopper. Each compartment contains different substances which are separately stored and later mixed together to form a liquid mixture for medical or paramedical purposes. The device is designed initially to provide storage of the different substances and later to insure proper mixing of the substances to form a liquid mixture and to dispense the same from the conditioning device.
The ampoule is closed at one end and open at the other end and comprises at least one cylindrical zone of narrow circular section, tapering to form a smaller area inside the ampoule and at least one cylindrical zone of a wide circular cross-section. During the storage phase, the narrow circular cylindrical section is tightly sealed, at one end, by the movable intermediary elastomeric plug so as to form a first compartment inside the ampoule which is disposed between the closed end of the ampoule and the moveable intermediary plug. The second compartment is disposed between the moveable intermediary plug and the open end of the ampoule, with the open end of the ampoule being closed by a piston-valve. During mixing of the two substances, the moveable intermediary plug is forced from the narrow circular cylindrical zone into the wider circular cylindrical zone to allow communication between the first and second compartments and mixing of the substances contained therein. The narrow circular cylindrical zone remains blocked by the piston valve. During dispensing, the piston valve is forced inside the ampoule to evacuate the liquid mixture from the ampoule.
U.S. Pat. No. 3,563,415 describes a distributor of liquid droplets comprising a vessel with two compartments, one of which contains a powder and the other a liquid solvent. The two substances being designed for mixing into a liquid medication. These two compartments are separated by an intermediary plug held in position in a narrow neck during the storage phase of the distributor. The neck also contains a plug comprising a first element slidable within the neck and having a radial canal, and a second element disposed for adaptation on the first element to block said radial canal. The compartment storing the powder has a considerably larger diameter than the neck. At the time of use, the plug is driven into the neck. The pressure exerted by the liquid solvent in one of the compartments pushes the intermediary plug into the compartment holding the powder. Gravity pulls the intermediary plug into said compartment and mixing can take place. When the powder is completely dissolved by the liquid, the second element of the plug is removed, thereby opening the radial canal and causing the medication to flow.
This device does not lend itself to use as an injection syringe or a spray device. Its only use is as a two compartmented conditioning device, the liquid medication resulting from mixing the two components flowing outside of the container by means of gravity.
European Patent Application Published as No. 0 144 483 describes a syringe of the mixing type, comprising a syringe body which is divided, during the storage phase, into two compartments by means of an intermediary plug. The syringe body is essentially cylindrical and its distal extremity has a needle, while its posterior extremity is closed by a piston head. The syringe body has a lateral deformation approximately towards the center, for example, a convex curved portion defining the trajectory of origin for transferring the liquid from the posterior compartment to the anterior compartment or mixing chamber when the intermediary plug is forced to the top of this curved portion.
When the component in the anterior compartment during the storage phase is a lyophilisate, the original substance to be lyophilized, usually in liquid form,
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Howald Ernst
Meyer Gabriel
Lewis Ralph
Medicorp Holding S.A.
Pellegrino Stephen C.
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