Liquid purification or separation – Processes – Chromatography
Reexamination Certificate
2006-10-13
2010-12-07
Therkorn, Ernest G (Department: 1797)
Liquid purification or separation
Processes
Chromatography
C210S198200
Reexamination Certificate
active
07846335
ABSTRACT:
A device is provided for chromatographic separations comprising a manifold comprising a plurality of connectors for connecting to one or more chromatographic separation columns and/or feed or extraction tubing. At least one central duct is formed between at least two connectors forming an inlet and an outlet respectively. The central duct comprises a closable duct valve; and a plurality of branch ducts branching from the central duct to a branch connector. The branch duct comprises a closable branch valve, wherein at least one branch duct is positioned between the inlet and the central duct valve and wherein at least one branch duct is positioned between the outlet and the central duct valve. The device is arranged for carrying out single-column and (continuous) multicolumn chromatographic separations. This allows the purification of biopharmaceutical products without having to develop, demonstrate and validate cleaning procedures for the valves.
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PTO Translation No. 10-4137 of Eurpean Patent No. 3617.
International Search Report for PCT/NL2006/000519, mailed on Jan. 17, 2007, 2 pages.
Chin and Wang, Separation and Purification Reviews (2004) 33(2):77-155.
Bisschops Marc Antonius T.
Pennings Jozef Anton M.
Tijsterman Jacob Arthur
Morrison & Foerster / LLP
Therkorn Ernest G
Xendo Holding B.V.
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