Combinatorial chemistry technology: method – library – apparatus – Method of creating a library
Reexamination Certificate
2002-05-29
2010-11-23
Lundgren, Jeffrey S. (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Method of creating a library
C435S006120, C506S007000, C506S013000
Reexamination Certificate
active
07838466
ABSTRACT:
This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In particular, the present invention provides methods and devices for selectively converting photogenerated reagent precursors to photogenerated reagents comprising a substrate comprising at least one solid surface containing a plurality of isolated reaction sites; and an optical system operably linked to the substrate comprising a light source and a computer-controlled spatial optical modulator to form an irradiation pattern, wherein the irradiation pattern selectively irradiates a plurality of reaction sites without use of a photolithographic mask. The method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.
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Simpson, P., et al.,ȁ
Gao Xiaolian
Gulari Erdogan
Zhou Xiaochuan
Casimir Jones S.C.
Lundgren Jeffrey S.
The Regents of the University of Michigan
University of Houston
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