Combinatorial chemistry technology: method – library – apparatus – Method of creating a library – Liquid-phase synthesis or particular method of cleavage from...
Reexamination Certificate
2002-09-11
2009-02-17
Schultz, J D (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Method of creating a library
Liquid-phase synthesis or particular method of cleavage from...
C506S013000, C506S033000, C435S006120
Reexamination Certificate
active
07491680
ABSTRACT:
This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. In some embodiments, the present invention provides methods and devices for generating one or more selected multimers at specific reaction sites on a substrate comprising contacting the substrate with a liquid solution comprising photo-reagent precursors, isolating the reaction sites, selectively irradiating the reaction sites with a digital micromirror device, and contacting the substrate with monomers. The method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.
REFERENCES:
patent: 4146329 (1979-03-01), King et al.
patent: 4163150 (1979-07-01), Stankewitz
patent: 4301363 (1981-11-01), Suzuki et al.
patent: 4367251 (1983-01-01), Crivello
patent: 4571603 (1986-02-01), Hornbeck et al.
patent: 4596992 (1986-06-01), Hornbeck
patent: 4615595 (1986-10-01), Hornbeck
patent: 4662746 (1987-05-01), Hornbeck
patent: 4719615 (1988-01-01), Feyrer
patent: 5028939 (1991-07-01), Hornbeck et al.
patent: 5096279 (1992-03-01), Hornbeck et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5158855 (1992-10-01), Sugiyama
patent: 5202231 (1993-04-01), Drmanac et al.
patent: 5247180 (1993-09-01), Mitcham et al.
patent: 5252743 (1993-10-01), Barrett et al.
patent: 5318679 (1994-06-01), Nishioka
patent: 5324483 (1994-06-01), Cody et al.
patent: 5384261 (1995-01-01), Winkler et al.
patent: 5393877 (1995-02-01), McLean et al.
patent: 5401607 (1995-03-01), Takiff
patent: 5401837 (1995-03-01), Nelson
patent: 5405783 (1995-04-01), Pirrung et al.
patent: 5412087 (1995-05-01), McGall et al.
patent: 5424186 (1995-06-01), Fodor et al.
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5451683 (1995-09-01), Barrett et al.
patent: 5474796 (1995-12-01), Brennan
patent: 5482867 (1996-01-01), Barrett et al.
patent: 5489678 (1996-02-01), Fodor et al.
patent: 5504614 (1996-04-01), Webb et al.
patent: 5510270 (1996-04-01), Fodor et al.
patent: 5517280 (1996-05-01), Quate
patent: 5535047 (1996-07-01), Hornbeck
patent: 5539567 (1996-07-01), Lin et al.
patent: 5539568 (1996-07-01), Lin et al.
patent: 5552471 (1996-09-01), Woo
patent: 5556752 (1996-09-01), Lockhart et al.
patent: 5578832 (1996-11-01), Trulson et al.
patent: 5583688 (1996-12-01), Hornbeck
patent: 5585481 (1996-12-01), Arnold, Jr.
patent: 5593839 (1997-01-01), Hubbell
patent: 5599695 (1997-02-01), Pease et al.
patent: 5600383 (1997-02-01), Hornbeck
patent: 5623049 (1997-04-01), LobberDing
patent: 5625052 (1997-04-01), Woo
patent: 5631734 (1997-05-01), Stern et al.
patent: 5653939 (1997-08-01), Hollis et al.
patent: 5656741 (1997-08-01), Chow
patent: 5656744 (1997-08-01), Arnold, Jr.
patent: 5666190 (1997-09-01), Quate et al.
patent: 5677195 (1997-10-01), Winkler
patent: 5695940 (1997-12-01), Drmanac et al.
patent: 5738829 (1998-04-01), Kempe
patent: 5739386 (1998-04-01), Holmes
patent: 5744305 (1998-04-01), Fodor et al.
patent: 5750672 (1998-05-01), Kempe
patent: 5753788 (1998-05-01), Fodor et al.
patent: 5768009 (1998-06-01), Little
patent: 5831070 (1998-11-01), Pease et al.
patent: 5835256 (1998-11-01), Huibers
patent: 5837832 (1998-11-01), Chee et al.
patent: 5869696 (1999-02-01), Reddy et al.
patent: 5883705 (1999-03-01), Minne et al.
patent: 5919523 (1999-07-01), Sundberg
patent: 5936759 (1999-08-01), Buttner
patent: 5953153 (1999-09-01), Conner et al.
patent: 5958268 (1999-09-01), Engelsberg
patent: 5959098 (1999-09-01), Goldberg
patent: 5991066 (1999-11-01), Robinson
patent: 6005125 (1999-12-01), Zhang
patent: 6015895 (2000-01-01), Pon
patent: 6031091 (2000-02-01), Arnold, Jr.
patent: 6043353 (2000-03-01), Pon
patent: 6051374 (2000-04-01), Simons
patent: 6083697 (2000-07-01), Beecher et al.
patent: 6090934 (2000-07-01), Kumar et al.
patent: 6210878 (2001-04-01), Pinkel
patent: 6215579 (2001-04-01), Bloom et al.
patent: 6271957 (2001-08-01), Quate et al.
patent: 6295153 (2001-09-01), Garner
patent: 6375903 (2002-04-01), Cerrina et al.
patent: 6426184 (2002-07-01), Gao
patent: 6465175 (2002-10-01), Horn
patent: 6480324 (2002-11-01), Quate et al.
patent: 6542241 (2003-04-01), Thorwirth
patent: 2003/0138363 (2003-07-01), Gao
patent: 2003/0143131 (2003-07-01), Gao
patent: 2003/0186226 (2003-10-01), Brennan
patent: 2003/0186427 (2003-10-01), Gao et al.
patent: 2004/0023368 (2004-02-01), Gao et al.
patent: 692 18 572 (1993-07-01), None
patent: 0537524 (1993-04-01), None
patent: 0 961 174 (1999-12-01), None
patent: 93/02992 (1993-02-01), None
patent: 93/09668 (1993-05-01), None
patent: WO 93/22678 (1993-11-01), None
patent: 96/11878 (1996-04-01), None
patent: WO 97/26569 (1997-07-01), None
patent: WO 97/39151 (1997-10-01), None
patent: 98/20967 (1998-05-01), None
patent: 99/41007 (1999-08-01), None
patent: WO 99/42813 (1999-08-01), None
patent: WO 99/63385 (1999-12-01), None
patent: 00/12524 (2000-03-01), None
patent: WO 00/13017 (2000-03-01), None
patent: 00/46231 (2000-08-01), None
patent: WO 00/47598 (2000-08-01), None
patent: 01/96357 (2001-12-01), None
McGall et al., “Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists”, 1996, PNAS, 93(24), pp. 13555-13560.
Sampsell, Jeffrey B., “Digital micromirror device and its application to projection displays”, 1994, J. Vac. Sci. Technol. B, 12(6), pp. 3242-3246.
Chrisey et al., “Fabrication of Patterned DNA Surfaces,”Nucleic Acids Res. 24(15):3040-3047 (1996).
Davidson, “A Microlans Direct-Write Concept for Lithography,”SPIE3048:346-355 (1997).
Editorial, “To Affinity . . . and Beyond!,”Nature Genetics14(4):367-370 (1996).
Feldman and Pevzner, “Gray Code Masks for Sequencing by Hybridization,”Genomics23:233-235 (1993.
Fink and Christiansen,Electronics Engineers Handbook, 3.sup.rd ed., McGraw Hill, pp. 11-96 and 11-99 (1989).
Forman et al., “Thermodynamics of Duplex Formation and Mismatch Discrimination on Photolithographically Synthesized Oligonucleotide Arrays,”Molecular Modeling of Nucleic Acids, American Chemical Society Symposium Series, 206-228 (Apr. 13-17, 1997).
Garner, “Automating the Genome Center,”IEEE Engineering in Medicine and Biology, pp. 281-283 (1994).
Goodall et al., “Excimer Laser Photolithography with 1:1 Wynne-Dyson Optics,” SPIE vol. 922,Optical/Laser Microlithography(1988).
Groves et al., “Micropatterning Fluid Lipid Bilayers on Solid-Supports,”Science275(5300):651-653 (1997).
Kerth et al., “Excimer Laser Projection Lithography on a Full-Field Scanning Projection System,”IEEE Electron Device Letters, EDL-7(5):299-301 (1986).
Kim et al., “Polymer Microstructures Formed by Moulding in Capillaries,”Nature376:581-584 (1995).
Kuck et al., “New system for Fast submicron laser direct writing,”SPIE2440:506-514 (1995).
Neff et al., “Two-Dimensional Spatial Light Modulators: A Tutorial,”Proceedings of the IEEE78(5):826-855 (1990).
O'Brien et al., “Astral, a Hyperspectral Imaging DNA Sequencer,”Review of Scientific Instruments69(5):2141-2146 (1998).
Park et al., “Block Copolymer Lithography:Periodic Arrays of 1011 Holes in 1 Square Centimeter,”Science276:1401-1404 (1997).
Paufler et al., “High-throughput optical direct write lithography,” Solid State Technology pp. 175-182 (1997).
Ruff et al., “Broadband Deep-UV High NA Photolithography System,”Optical/Laser Microlithography II, SPIE1088:441-446 (1989).
Seltmann et al., “New System for Fast Submicron Optical Direct Writing,”Microelectronic Engineering30:123-127 (1996).
Singh-Gasson et al., “Maskless fabrication of light-directed oligonucleotide microarrays using a digital Micromirror array,”Nature Biotechnology17:974-978 (1999).
Strachan et al., “A New Dimension for the Human Genome Project: Towards Comprehensive Expression Maps,”Nature Genetics16:126-132 (1997).
Sund
Gao Xiaolian
Gulari Erdogan
Zhou Xiaochuan
Casimir Jones S.C.
Lundgren Jeffrey S.
Schultz J D
The Regents of the University of Michigan
University of Houston
LandOfFree
Device for chemical and biochemical reactions using... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Device for chemical and biochemical reactions using..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Device for chemical and biochemical reactions using... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4111449