Surgery – Respiratory method or device – Means for mixing treating agent with respiratory gas
Patent
1995-10-27
1999-10-05
Lewis, Aaron J.
Surgery
Respiratory method or device
Means for mixing treating agent with respiratory gas
12820014, 12820423, A61M 1100
Patent
active
059607920
ABSTRACT:
A method of treating human patients is provided by the intrapulmonary delivery of a pharmaceutically active peptide formulation. The formulation is automatically released in an aerosolized form from a hand-held, self-contained, portable device comprised of a means for automatically releasing a measured amount of drug into the inspiratory flow path of a patient in response to information obtained from a means for measuring the inspiratory flow rate and determining the inspiratory volume of a patient. Reproducible dosing is obtained by providing for automatic release at the same inspiratory flow rate and inspiratory volume each time drug is released. The device includes a timer to enable a patient to take a drug at the same time each day. Further, overadministration of hormone formulations is avoided by providing a pre-programmed microprocessor designed to avoid overdosing.
REFERENCES:
patent: 3812854 (1974-05-01), Michaels et al.
patent: 3991304 (1976-11-01), Hillsman
patent: 4106503 (1978-08-01), Rosenthal et al.
patent: 4361401 (1982-11-01), Smith et al.
patent: 4604847 (1986-08-01), Moulding, Jr. et al.
patent: 4627432 (1986-12-01), Newell et al.
patent: 4677975 (1987-07-01), Edgar et al.
patent: 4686231 (1987-08-01), Bender et al.
patent: 4819629 (1989-04-01), Jonson
patent: 4877989 (1989-10-01), Drews et al.
patent: 4926852 (1990-05-01), Zoltan et al.
patent: 4934358 (1990-06-01), Nilsson et al.
patent: 4984158 (1991-01-01), Hillsman
patent: 5011678 (1991-04-01), Wang et al.
patent: 5167506 (1992-12-01), Kilis et al.
patent: 5172686 (1992-12-01), Anthony
patent: 5363842 (1994-11-01), Mishelevich et al.
patent: 5394866 (1995-03-01), Ritson et al.
patent: 5404871 (1995-04-01), Goodman et al.
patent: 5450336 (1995-09-01), Rubsamen et al.
patent: 5497944 (1996-03-01), Weston et al.
patent: 5743250 (1998-04-01), Gonda et al.
Newman, S.P. et al. "How Should a Pressurized .beta.-Adrenergic Bronchodilator Be Inhaled?", Eur. J. Respir. Dis., 62:3-21, 1981.
Adjei, A. et al., "Pulmonary Delivery of Peptide Drugs: Effect of Particle Size on Bioavailability of Leuprolide Acetate in Healthy Male Volunteers", Pharmaceutical Research, 1990, 7:565-567.
Adjei, A. et al., "Bioavailability of leuprolide following intratracheal administration to beagle dogs", 1990, International Journal of Pharmaceutics, 61:135-144.
Barrowcliffe, M. et al., "Pulmonary clearance of vasoactive intestinal peptide", 1986, Thorax 41:88-93.
Braquet, P., "Effect of endothelin-1 on blood pressure and bronchopulmonary system of the guinea pig", 1989, Journal of Cardiovascular Pharmacology, 13(Suppl. 5):S143-S146.
Camp, J., "Patient-controlled analgesia", 1991, AFP, 44:2145-2150.
Colthorpe, P. et al., "The Pharmacokinetics of Pulmonary-Delivered Insulin: A Comparison of Intratracheal and Aerosol Administration to the Rabbit", 1992, Pharmaceutical Research, 9:764-768.
Debs, R. et al., "Lung-specific delivery of cytokines induces sustained pulmonary and systemic immunomodulation in rats", 1988, Journal of Immunology, 140:3482-3488.
Gourlay, G.K., "Fentanyl Blood Concentration-Analgesic Response Relationship in the Treatment of Postoperative Pain", 1988, Anesth. 67:329-337.
Harrison, T.R. et al., Harrison's Principles of Internal Medicine (10th edition), 1983, pp. 666-674.
Hubbard, R.C. et al., "Anti-Neutrophil-Elastase Defenses of the Lower Respiratory Tract in a1-Antitrypsin Deficiency Directly Augmented with an Aerosol of a1-Antitrypsin", Annals of Internal Medicine, 111:206-212.
Hubbard, R.C. et al., "Fate of aerosolized recombinant DNA-produced a1-antitrypsin:Use of the epithelial surface of the lower respiratory tract to adminster proteins of therapeutic importance", 1989, Proc. Natl. Acad. Sci. USA 86:680-684.
Jaffe, A.B., et al., "Rats self-administer Sufentanil in Aerosol Form", 1989, Psychopharmacology, 99:289-293.
Kohler, D., "Aerosols for Systemic Treatment", 1990, Lung, Suppl.:677-684.
Laube, Beth L. et al., "Aerosolized Insulin Delivered Through The Lungs Is Effective In Normalizing Plasma Glucose Levels In Non-Insulin Dependent Diabetic Subjects", 1991, J. Aerosol Medicine, 4:286.
Laube, Beth L., "Preliminary Study of the Efficacy of Insulin Aerosol Delivered by Oral Inhalation in Diabetic Patients", 1993, JAMA 269:2106-2109.
Lee, V.H., "Changing Needs in Drug Delivery in the Era of Peptide and Protein Drugs", Marcel Dekker, N.Y., pp. 1-11.
Lehman, K.A. et al., 1991, "Transdermal Fentanyl for the Treatment of Pain After Major Urological Operations", Eur. J. Clin. Phamacol. 41:17-21.
Mather, L.E., "Pharmaceokinetics and Patient-Controlled Analgesia(*)", 1992, Acta Anaesthesiologica Belgica, 43:5-20.
Miller, R., "Anesthesia Second Edition", 1986, Churchill Livingstone, 1:762.
Moses et al., Insulin Administered Intranasally as an Insulin-Bile Salt Aerosol--Effectiveness and Reproducibility in Normal and Diabetic Subjects, 1983, Diabetes 32:1040-1047.
Newman, S.P. et al., "Deposition of pressurized suspension aerosols inhaled through extension devices", 1981, Am. Rev. Respir. Dis. 124:317-320.
Newman, S.P. et al., "Deposition of Pressurized Aerosols in the Human Respiratory Tract", 1981, Thorax, 36:52-55.
Newman, S.P., "Deposition and Effects of Inhalation Aerosols", 1983, (2nd ed.) Churchill Livingstone.
Nieminen et al., "Aerosol Deposition in Automatic Dosimeter Nebulization" 1987, European Journal of Respiratory Diseases, 71:145-152.
Patton, J.S. et al., "Routes of Delivery: Case Studies-Pulmonary delivery of peptides and proteins for systemic action", 1992, Advanced Drug Delivery Reviews, 8:179-196.
Rapp, R.P. et al., Patient-controlled analgesia:a review of effectiveness of therapy and an evaluation of currently available devices, 1989, DICP, The Annals of Pharmacotherapy 23:899-904.
Rosenberg, M., "Patient-Controlled Analgesia", 1992, J. Oral Maxillofac. Surg. 50:386-389.
Rowbotham, D.J., "A disposable device for patient-controlled analgesia with fentanyl", 1989, Anaesthesia, 44:922-924.
Ryder, E., "The history of patient-controlled analgesia", 1991, Journal of Intravenous Nursing, 14(6):372-381.
Salzman, R., et al., Intranasal Aerosolized Insulin Mixed-Meal Studies and Long-Term Use in Type I Diabetes, 1985, New England Journal of Medicine, 213:1078-1084.
Shade, P., "Patient-controlled Analgesia: Can Client Education Improve Outcomes?", 1992, Journal of Advanced Nursing, 17:408-413.
Smith, Robert M., et al., "Pulmonary Deposition and Clearance of Aerosolized Alpha-1-Proteinase Inhibitor Administered to Dogs and to Sheep", 1989, J. Clin. Invest. 84:1145-1154.
Smythe, M., "Patient-controlled Analgesia:A Review", 1992, Pharmacotherapy, 12:132-143.
Wearley, Lorraine L., "Recent Progress in Protein and Peptide Delivery by Noninvasive Routes", 1991, Critical Reviews in Therapeutic Drug Carrier Systems, 8:331-392.
Wigley, F.M. et al., "Insul in Across Respiratory Mucosae by Aerosol Delivery" 1971, Diabetes, 20:552-556.
Yoshida et al., "Absorption of Insulin Delivered to Rabbit Trachea Using Aerosol Dosage Form" Journal of Pharmaceutical Sciences, 68(5):670-671 (1979).
Lloyd Lester J.
Lloyd Peter M.
Rubsamen Reid M.
Schuster Jeffrey A.
Aradigm Corporation
Bozicevic Karl
Lewis Aaron J.
LandOfFree
Device for aerosolized delivery of peptide drugs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Device for aerosolized delivery of peptide drugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Device for aerosolized delivery of peptide drugs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1160545