Surgery – Respiratory method or device – Means for mixing treating agent with respiratory gas
Patent
1996-06-19
1998-10-13
Weiss, John G.
Surgery
Respiratory method or device
Means for mixing treating agent with respiratory gas
12820014, 12820022, 12820023, 12820516, A61M 1500, B05B 1706
Patent
active
058197303
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to a device for administering pharmaceutical substances. The device delivers the pharmaceutical by means of a spraying action and is particularly adapted for intranasal administration of a predetermined dose of a pharmaceutical substance.
Devices for administering pharmaceutical substances by spraying are known, for example ones using aerosol canisters for treatment of asthma. In a different medical area, it is known to use capsules of pharmaceutical substances which can be cut or squeezed open to pour the contents onto a cloth or into water, for example to relieve blocked nasal passages. Such capsules are formed of plastics material. Nasal sprays are also well known, in which a container is placed at a nasal cavity and squeezed by hand, thereby spraying the contents out through a nozzle.
International patent publication No. W088/02266 discloses a container for delivery of a liquid medicine, in particular for intranasal delivery. The container body has a squeezable chamber filled with air and a chamber filled with the medicine, the two chambers being separated by a wall with a one-way valve formed therein. Upon removal of a cap, the medicine can be delivered through an orifice in the second chamber by squeezing the first chamber between the user's finger and thumb.
UK patent application No. 2255918 discloses a dispensing device comprising a magazine of cartridges full of a fluid to be atomised. The cartridges are fed in turn to a space below a spring-loaded plunger. On actuation, the plunger impacts upon the cartridge to pressurize the contents and eject them through atomising means which form part of the cartridge. The atomising orifice can be covered with a thin layer of plastic film or wax which ruptures at use or is removed prior to use. In an alternative arrangement, cartridges are inserted into the device one at a time, eliminating the need for a magazine holder.
U.S. Pat. No. 4,961,727 also describes a device for delivering a medicine to the nasal cavities. The device consists of a flexible-walled container having a discharge head with a swirl chamber and a dip-tube depending from the swirl chamber into the container. In use, the container is squeezed by hand to drive liquid up the dip-tube and into the swirl chamber to be discharged into the nasal cavity in a "fountain" of relatively large droplets. The container can include a capsule of a medicinal product which is ruptured by squeezing of the container, the product then being mixed with the liquid in the container.
The present invention aims to provide a new device which is simple to use and is particularly adapted for administering medicaments to the nasal passages or respiratory tract. It will be appreciated by those skilled in the art that to be effective medicaments administered to the nasal cavities or respiratory tract are required to be delivered in a form in which they can be readily absorbed or otherwise reach the site of action of the medicaments. In general such medicaments are administered to the nasal cavities in a liquid carrier, the medicament being in the form of a solution or suspension in a pharmaceutically acceptable vehicle. The preferred means of administration is by presenting the liquid as a spray. It is further desirable that the medicament is maintained in a sterile form until use. Preferably a predetermined dose of a pharmaceutical substance is delivered to the nasal passages or respiratory tract.
The invention provides in a first aspect a device suitable for administering pharmaceutical substances by spraying the contents of a container formed of plastics material, the device comprising a pair of members for supporting the container, and a discharge outlet, wherein when the container is present one or both members are movable between a first position in which the container is not compressed sufficiently to burst it and a second position in which the members are capable of exerting sufficient pressure on the container to burst it, thereby expelling the contents through the discharge outlet.
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Christie John Alexander
Lockett Lynn Michelle
Oretti John Ernest
Riedel Ingo Helmuth
Stone Robert
Glaxo Wellcome Australia Ltd.
Srivastava V.
Weiss John G.
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