Device for administering drug transdermally which provides an in

Details Device for administering drug transdermally which provides an in Device for administering drug transdermally which provides an in

1991-10-10

1994-10-04

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Web, sheet or filament bases; compositions of bandages; or...

424447, 424449, A61F 1302

Patent

active

053524560

ABSTRACT:
A transdermal drug delivery device that administers drug in an initial pulse followed by a substantially lower continuous rate comprising a drug reservoir of the drug dissolved in a carrier and a volatile permeation enhancer confined between a backing that is permeable to the volatile permeation enhancer and an underlying substrate layer that is permeable to the drug, carrier and enhancer. When the device is placed on the skin the volatile permeation enhancer is depleted from the reservoir by evaporation through the backing such that the magnitude and duration of the pulse is dependent upon the permeability of the backing layer to the volatile enhancer.

REFERENCES:
patent: 4060084 (1977-11-01), Chandrasekran et al.
patent: 4379454 (1983-04-01), Campbell et al.
patent: 4460372 (1984-07-01), Campbell et al.
patent: 4698062 (1987-10-01), Gale et al.
patent: 4906463 (1990-03-01), Cleary et al.
patent: 4927632 (1990-05-01), Wong
patent: 4956181 (1990-09-01), Bayer et al.
Kondo, S., et al., J. Pharmacobio-Dyn. (1987) 10:662-668.

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