Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Patent
1995-05-09
1998-09-01
Chin, Christopher L.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
436523, 436529, 436533, 436541, 436807, 435 2, 4352841, 4352886, 435962, 422 56, 422 59, 422 73, 604 4, 604 5, 604 6, 604 7, 604 19, A61M 3700, A61M 130, G01N 33543
Patent
active
058010637
ABSTRACT:
A method and device is described for direct removal of heparin from whole blood during extracorporeal therapy. In clinical situations where the blood is heparinized to prevent clotting in the extracorporeal circuit containing e.g., a hemodialysis cartridge or a heart-lung machine, it would be desirable to eliminate the systemic heparinization of the patients. The extracorporeal circuit contains a device having antithrombin III immobilized and inserted between the outlet port of the primary extracorporeal device, such as the hemodialysis cartridge or heart-lung machine and the patient. When the heparinized blood comes in contact with the immobilized antithrombin III, heparin is removed and the reperfused blood is substantially free of heparin. The advantage of the system lies in the fact that heparin is removed from the blood rather than neutralized. This helps overcome the adverse reactions and side effects associated with the use of heparin anticoagulation.
REFERENCES:
patent: 4200690 (1980-04-01), Root et al.
patent: 4326532 (1982-04-01), Hammar
patent: 4411786 (1983-11-01), Russell
patent: 4450104 (1984-05-01), Jordan
patent: 5229268 (1993-07-01), Pry et al.
Hook et al., FEBS Letters, vol. 66 (1), pp. 90-93, Jul. 1976.
Jorpes J.E., Heparin in the Treatment of Thrombosis, pp. 100-104 and 116-129, 1946.
Wattrisse et al., Thrombosis Research, vol. 65 (1), S177--Abstract Only, 1992.
V. S. Hornsey et al., "Reductive Amination for Solid-Phase Coupling of Proteins", J. Immunol. Meth. 93: 83-88 (1986).
J. Porath, "General Methods and Coupling Procedures", Meth. Enzymol. 34: 13-30 (1974).
Grandics Peter
Szathmary Susan
Chin Christopher L.
Nguyen Bao-Thuy L.
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