Device and process for removing free hemoglobin from blood

Details Device and process for removing free hemoglobin from blood Device and process for removing free hemoglobin from blood

1993-11-08

1995-10-10

Kim, John

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210490, 210505, 210508, 210767, 435 2, 435179, 435181, 436177, 436 53, 530385, 530412, 530814, 530816, B01D 3700, B01D 3904, B01D 3908, B01D 1500

Patent

active

054568358

ABSTRACT:
A filter and a hollow-fiber or flat-sheet membrane for removing hemoglobin from whole blood or blood fractions are disclosed. The filter comprises a laid textile web which has been modified to attach a ligand for hemoglobin. The membrane comprises a polyethersulfone membrane that has been similarly modified. Methods for removing hemoglobin, cellular components and debris from blood are also disclosed.

REFERENCES:
patent: 4274914 (1981-06-01), Keith et al.
patent: 4925574 (1990-05-01), Hsia
patent: 5059654 (1991-10-01), Hou et al.
patent: 5190657 (1993-03-01), Heagle et al.
Hermanson et al. "Immobilized Affinity Ligand Techniques" Smith Academic Press, Inc. 51-132 (1992).
Dean et al. "Affinity Chromatography A practical Approach" IRL Press Ltd. 31-59 (1987).
Axen et al., "Chemical Coupling of Peptides and Proteins to Polysacchardies by Means of Cyanogen Halides" Nature 214, 1302-1304 (1967).
Cuatrecasas et al. "Selective Enzyme Purification by Affinity Chromatography" Proc. Natl. Acad. Sci. US 61, 636-643 (1968).
Lamed et al., "Covalent Coupling of Nucleotides to Agarose For Affinity Chromatography", Biochimica et Biophysica Acta, 304. 231-235 (1973).
Hou et al., "A Method for Extracorporeal Heparin Removal from Blood by Affinity Chromatography", Artif Organs, 14(6), 436-442 (1990).

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