Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis
Patent
1994-12-30
1999-01-05
Clarke, Robert A.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
623 16, 424487, A61F 202, A61K 914
Patent
active
058556087
ABSTRACT:
An anatomically specific, bioresorbable, implant device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment of using the implant device for facilitating the healing of a human joint lesion includes a cartilage region invested with an alginate microstructure joined with a subchondral bone region invested with a hyaluronan microstructure. The alginate selectively dispersed in the cartilage region enhances the environment for chondrocytes to grow articular cartilage. The hyaluronan selectively dispersed in the subchondral bone region enhances the environment for mesenchymal cells which migrate into that region's macrostructure and which differentiate into osteoblasts. The microstructures can be invested at varying concentrations in the regions. A hydrophobic barrier, strategically positioned within the subchondral bone region macrostructure, shields the chondrocytes from the oxygenated blood in subchondral cancellous bone. In the preferred form, the cartilage region includes a tangential zone including a network of intercommunicating void spaces having a horizontal orientation and in communication with synovial fluid and includes a radial zone including multiple void spaces oriented in both horizontal and vertical planes and providing intercommunication between the tangential zone and the subchondral bone region.
REFERENCES:
patent: 4186448 (1980-02-01), Brekke
patent: 4642120 (1987-02-01), Nevo et al.
patent: 5041138 (1991-08-01), Vacanti et al.
patent: 5133755 (1992-07-01), Brekke
patent: 5152791 (1992-10-01), Hakamatsuka et al.
patent: 5294446 (1994-03-01), Schlameus et al.
patent: 5366508 (1994-11-01), Brekke
Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads, by H.J. Hauselmann, M.B. Aydelotte, B.L. Schumacher, K.E. Kuettner, S.H. Gitelis, and E.J.-M.A. Thonar, Matrix, 12, pp. 116-129, (1992).
Towards a synthetic articular cartilage, by P.H. Corkhill, J.H. Fitton, and B.J. Tighe, J. Biomater. Sci. Polymer Edn., 4 (6), pp. 615-630, (1993).
Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers, by L.E. Freed, J.C. Marquis, A. Nohria, J. Emmanual, A.G. Mikos, and R. Langer, J. Biomed. Mat. Res., 27, pp. 11-23, (1993).
Porous polymer implants for repair of full-thickness defects of articular cartilage: an experimental study in rabbit and dog, by J. Klompmaker, H.W.B. Jansen, R.P.H. Veth, H.K.L. Nielsen, J.H. de Groot, and A.J. Pennings, Biomat., 13 (9), pp. 625-634, (1992).
Laminated three-dimensional biodegradable foams for use in tissue engineering, by A.G. Mikos, G. Sarakinos, S.M. Leite, J.P. Vacanti, and R. Langer, Biomat., 14 (5), pp. 323-330, (1993).
Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation, by A.G. Mikos, Y. Bao, L.G. Cima, D.E. Ingber, J.P. Vacanti, and R. Langer, J. Biomed. Mat. Res., 27, pp. 183-189, (1993).
Effect of freeze-dried poly-L-lactic acid discs mixed with bone morphogenetic protein on the healing of rat skull defects by T. Miki, K. Harada, Y. Imai, and S. Enomoto, J. Oral Maxillofac. Surg., 52, pp. 387-391, (1994).
Attachment and survival of perichondrocytes in a porous polylactic acid (PLA) matrix: an in vitro study, by C.R. Chu, A.Z. Monosov, R.D. Coutts, and D. Amiel, Thirteenth Southern Biomedical Engineering Conference, Apr. 16-17, 1994, University of the District of Columbia, Washington, D.C.
Identification of hyaluronic acid binding sites in the extracellular domain of CD44, by R.J. Peach, D. Hollenbaugh, I. Stamenkovic, and A. Aruffo, J. Cell Bio., 122 (1), pp. 257-264 (Jul. 1993).
Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition, by K. Miyake, C.B. Underhill, J. Lesley, and P.W. Kincade, J. Exp. Med., 172, pp. 69-75, (1990).
Expression and modulation of CD44 variant isoforms in humans, by C.R. Mackay, H-J. Terpe, R. Stauder, W.L. Marston, H. Stark and U. Gunthert, J. Cell Bio., 124 (1&2), pp. 71-82, (Jan. 1994).
Culture and differentiation of chondrocytes entrapped in alginate gels, by M. Grandolfo, P. D'Andrea, S. Paoletti, M. Martina, G. Silvestrini, E. Bonucci, and F. Vittur, Calcif. Tissue Int., 52, pp. 42-48, (1993).
Influence of matricial molecules on growth and differentiation of entrapped chondrocytes, by H. Ramdi, C. Legar, and M. Lievremont, Experi. Cell Res., 207, pp. 449-454, (1993).
Rabbit articular chondrocytes in alginate gel: characterisation of immobilized preparations and potential applications, by C. Tamponnet, H. Ramdi, J-B. Guyot, and M. Lievremont, Appl. Microbiol. Biotechnol., 37, pp. 311-315, (1992).
Brekke John H.
Ringeisen Timothy
Clarke Robert A.
THM Biomedical, Inc.
LandOfFree
Device and methods for in vivo culturing of diverse tissue cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Device and methods for in vivo culturing of diverse tissue cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Device and methods for in vivo culturing of diverse tissue cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-857918