Surgery – Liquid medicament atomizer or sprayer – Gas stream aspirating medicament from reservoir
Patent
1995-10-27
1999-08-10
Lewis, Aaron J.
Surgery
Liquid medicament atomizer or sprayer
Gas stream aspirating medicament from reservoir
12820014, 12820423, A61M 1100
Patent
active
059342722
ABSTRACT:
Devices, packaging and methodology for efficiently and repeatably creating aerosolized bursts of a formulation of respiratory drug are disclosed. Devices are hand-held, self-contained units which are automatically actuated at the same release point in a patient's inspiratory flow cycle. The release point is automatically determined either mechanically or, more preferably calculated by a microprocessor which receives data from a sensor making it possible to determine inspiratory flow rate and inspiratory volume. The device is loaded with a cassette comprised of an outer housing which holds a package of individual collapsible containers of formulation which comprises a respiratory drug useful in topically treating lung tissue. Actuation of the device forces respiratory drug through a porous membrane of the container which membrane has pores having a diameter in the range of about 0.25 to 6.0 microns. The porous membrane is positioned in alignment with a surface of a channel through which a patient inhales air. The flow profile of air moving through the channel is such that the flow at the surface of the channel is less than the flow rate at the center of the channel. The membrane is designed so that it protrudes outward at all times or is made flexible so that when respiratory drug formulation is forced against and through the membrane the flexible membrane protrudes outward beyond the flow boundary layer of the channel into faster moving air. Because the membrane protrudes into the faster moving air of the channel the particles of aerosol formed are less likely to collide allowing for the formation of a burst of fine aerosol mist with uniform particle size.
REFERENCES:
patent: 3812854 (1974-05-01), Michaels et al.
patent: 3923057 (1975-12-01), Chalon
patent: 3991304 (1976-11-01), Hillsman
patent: 4090642 (1978-05-01), Baker
patent: 4361401 (1982-11-01), Smith et al.
patent: 4604847 (1986-08-01), Moulding, Jr. et al.
patent: 4621632 (1986-11-01), Bartels et al.
patent: 4627432 (1986-12-01), Newell et al.
patent: 4686231 (1987-08-01), Bender et al.
patent: 4877989 (1989-10-01), Drews et al.
patent: 4926852 (1990-05-01), Zoltan et al.
patent: 4984158 (1991-01-01), Hillsman
patent: 5167506 (1992-12-01), Kilis et al.
patent: 5172686 (1992-12-01), Anthony
patent: 5363842 (1994-11-01), Mishelevich et al.
patent: 5394866 (1995-03-01), Ritson et al.
patent: 5404871 (1995-04-01), Goodman et al.
patent: 5450336 (1995-09-01), Rubsamen et al.
patent: 5497944 (1996-03-01), Weston et al.
patent: 5743250 (1998-04-01), Gonda et al.
Camp, J.P., "Patient-Controlled Analgesia", 1991, AFP Clinical Pharmacology, 44:2145-2150.
Colthorpe, P. et al., "The pharmacokinetics of Pulmonary-Delivered Insulin:A comparison of intratracheal and aerosol administration to the rabbit", 1992, Pharmaceutical Research, 9:764-768.
Daman, H.R., "Pulmonary function testing:Use of the peak expiratory flow rate in an out-patient or office setting", 1984, Journal of Asthma, 21:331-337.
Evans, R. et al., "National trends in the morbidity and mortality of asthma in the US", 1987, Chest, 91(Supp.):65S-74S.
Gourlay, G.K. et al., "Fetanyl blood concentration-analgesic response relationship in the treatment of postoperative pain", 1988, Anesth. Analg. 67:329-337.
Jackson, R. et al., "International trends in asthma mortality: 1970 to 1985", 1988, Chest, 94:914-919.
Jaffe, A.B. et al., Rats self-administer sufentanil in aerosol form.
Janson-Bjerklie, S. et al., "Effect of peak flow information on patterns of self-care in adult asthma", 1988, Heart & Lung, 17:543-549.
Kohler, D., "Aerosols for Systemic Treatment", 1990, Lung, Suppl.:677-684.
Lauber, B.L. et al., "Deposition, Clearance, and Effects in the Lung", Journal of Aerosol Medicine, 4:286.
Lehmann, K.A. et al., "Transdermal fentanyl for the treatment of pain after major urological operations", 1991, Eur. J. Clin. Pharmacol. 41:17-21.
Malo, J. et al., Four-times-a-day dosing frequency is better than a twice-a-day regimen in subjects requiring a high-dose inhaled steroid, budesonide, to control moderate to severe asthma, 1989, Am. Rev. Respir. Dis. 140:624-628.
Mather, J.E., "Pharmacokinetics and patient-controlled analgesia(*)", 1992, Acta Anaesthesiologica Belgica 43:5-20.
Miller, R., "Anaesthesia", (2nd Edition), 1986, Churchill Livingstone, 1:762.
Moses, A.C. et al., Insulin administered intranasally as an insulin-bile salt aerosol-Effectiveness and Reproducibility in Normal and Diabetic Subjects, 1983, Diabetes, 32:1040-1047.
Newman, S.P. et al., "Deposition of pressurized aerosols in the human respiratory tract", 1981, Thorax, 36:52-55.
Newman, S.P. et al., "How should a pressurized .beta.-adrenergic bronchodilator be inhaled?", 1981, Eur. J. Respir. Dis. 62:3-21.
Newman, S.P. et al., "Deposition of pressurized suspension aerosols inhaled through extension devices", 1981, Am. Rev. Respir. Dis. 124:317-320.
Newman, S.P., "Deposition and Effects of Inhalation Aerosols", 1983, (2 ed.), Churchill Livingstone.
Nieminen, M.M., "Aerosol deposition in automatic dosimeter nebulization", 1987, Eur. J. Respir. Dis. 71:145-152.
Nowak, R. et al., Comparison of peak expiratory flow and FEV.sub.1 admission criteria for acute bronchial asthma, 1982, Annals of Emergency Medicine, 11:64-69.
Rapp, R.P. et al., Patient-controlled analgesia:A review of effectiveness of therapy and an evaluation of currently available devices, 1989, DICP, The Annals of Pharmacotherapy 23:899-904.
Rosenberg, M., "Patient-controlled analgesia", 1992, J. Oral Maxillofac. Surg. 50:386-389.
Rowbotham, D.J. et al., "A disposable device for patient-controlled analgesia with fentanyl", 1989, Anaesthesia, 44:922-924.
Ryder, E., "The history of patient-controlled analgesia", 1991, Journal of Intravenous Nursing 14:372-381.
Salzman, R.,"Intranasal aerosolized insulin mixed-meal studies and long-term use in type 1 diabetes", 1985, New England Journal of Medicine, 213:1078-1084.
Sears et al., "Increasing asthma mortality--fact or artifact?", 1988, Journal of Allergy and Clinical Immunology, 82:957-960.
Shade, P., "Patient-controlled analgesia:can client education improve outcomes?", 1992, Journal of Advanced Nursing, 17:408-413.
Shim, Chang et al., "Evaluation of the severity of asthma:Patients versus physicians", American Journal of Medicine, 68:11-13.
Smythe, M., "Patient-controlled analgesia:A review", 1992, Pharmacotherapy, 12:132-143.
Spitzer, W.O. et al., "The Use of .beta.-agonists and the risk of death and near death from asthma", 1992, N. Engl. J. Med. 326:501-506.
Wigley, F.M. et al., "Insulin across respiratory mucosae by aerosol delivery", 1971, Diabetes 20:552-556.
Williams, Jr., H., "Expiratory flow rates:Their role in asthma therapy", 1982, Hospital Practice 10:95-110.
Yoshida, H. et al., "Absorption of insulin delivered to rabbit trachea using aerosol dosage form", 1979, J. Pharmaceutical Sciences, 68:670-671.
Lloyd Lester J.
Lloyd Peter M.
Rubsamen Reid M.
Schuster Jeffrey A.
Aradigm Corporation
Bozicevic Karl
Lewis Aaron J.
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