Device and method for treatment of wounds with nitric oxide

Surgery – Means for introducing or removing material from body for... – Gas application

Reexamination Certificate

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Details

C604S290000, C604S289000, C604S540000, C604S543000, C424S718000

Reexamination Certificate

active

07122018

ABSTRACT:
Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing and preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used to reduce the microbial infection, manage exudates secretion by reducing inflammation, upregulate expression of endogenous collagenase to locally debride the wound, and regulate the formation of collagen. High concentration of nitric oxide ranging from 160–400 ppm may be used without inducing toxicity in the healthy cells around a wound site. Exposure to the high concentration for a first treatment period reduces the microbial burden and inflammation, and increases collagenase expression to debride necrotic tissue at the wound site. After a first treatment period, a second treatment period at a lower concentration of nitric oxide, preferably ranging from 5–20 ppm may be used to restore the balance of nitric oxide and induce collagen expression aiding in the wound closure.

REFERENCES:
patent: 5154697 (1992-10-01), Loori
patent: 5514204 (1996-05-01), Sheu et al.
patent: 5519020 (1996-05-01), Smith et al.
patent: 5688236 (1997-11-01), Gragg
patent: 6060020 (2000-05-01), Piuk et al.
patent: 6071254 (2000-06-01), Augustine
patent: 6073627 (2000-06-01), Sunnen
patent: 6083209 (2000-07-01), Marasco, Jr.
patent: 6103275 (2000-08-01), Seitz et al.
patent: 6110895 (2000-08-01), Rodgers et al.
patent: 6160021 (2000-12-01), Lerner et al.
patent: 6190704 (2001-02-01), Murrell
patent: 6747062 (2004-06-01), Murrell
patent: 6793644 (2004-09-01), Stenzler
patent: 2002/0138051 (2002-09-01), Hole et al.
patent: 2002/0155164 (2002-10-01), Figley et al.
patent: 2003/0165578 (2003-09-01), Murrell
patent: 2004/0043026 (2004-03-01), Tuan et al.
patent: WO 00/07653 (2000-02-01), None

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