Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2005-08-30
2005-08-30
Azpuru, Carlos A. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
Reexamination Certificate
active
06936270
ABSTRACT:
A therapeutically effective compound is locally administered by associating the compound with a piece of orthopedic hardware that is implanted at an appropriate site within a body. The compound is adapted, such as through a sustained release device, to administer an effective dosage continuously over an extended period of time. The compound may be administered, for example, to a joint of a mammal by intraarticularly implanting a sustained release device to deliver the therapeutically effective compound within a synovial capsule of the joint, such that synovial fluid concentration of the compound is greater than plasma concentration of the compound. A wide range of orthopedic hardware, such as bone screws and staples, may be adapted to use in the systems described herein to provide treatment for a variety of medical conditions.
REFERENCES:
patent: 5902598 (1999-05-01), Ashton et al.
patent: 6001386 (1999-12-01), Ashton et al.
patent: 6051576 (2000-04-01), Cynkowsk et al.
patent: 0 911 025 (1999-05-01), None
patent: WO9717032 (1997-05-01), None
patent: WO0042929a (2000-07-01), None
Illi et al: “stimulation of Fracture healing by Local Application of Humoral factors Integrated in Biodegradable Implants”, European Journal of Pediatric Surgery: Official Journal of Austrian Association of Pediatric Surgery, Aug. 1998, vol. 8, No. 4.
Bias, P. et al. Sustained-Release Dexamethasone Palmitate: Pharmacokinetics and Efficacy in Patients with Activated Inflammatory Osteoarthritis of the Knee. Clinical Drug Investigation 6, 429-436 (2001).
Brown, K. et al. A Novel Controlled-Release Intraarticular Delivery System. Arthritis and Rheumatism 9, S267 (Nov. 7, 1993).
Derendorf, H. et al. Aktuelle Rheumatologie. 15, 145-153 (1990)—[English Abstract].
Ashton Paul
Chen Jianbing
Laporte Richard
Smith Thomas J.
Watson David A.
Azpuru Carlos A.
Control Delivery Systems, Inc.
Ropes & Gray LLP
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