Chemistry: analytical and immunological testing – Clotting or clotting factor level tests
Patent
1982-12-20
1985-09-24
Richman, Barry S.
Chemistry: analytical and immunological testing
Clotting or clotting factor level tests
422 56, 435 13, 436169, 436170, 427 2, G01N 3348
Patent
active
045433356
ABSTRACT:
A device for the quantitative determination of heparin in mammalian blood plasma, a method for the preparation of such device and a method for determining the plasma's heparin concentration using the device. The device, which is prepared using a freeze-drying technique, comprises a first upper layer of a carrier matrix material containing a buffer, AT-III and thrombin and a second, lower layer of a carrier matrix containing a thrombin sensitive fluorogenic or chromogenic substrate being capable of interacting with thrombin in such a manner that a time-related chemical change detectable by fluorometric or spectrophotometric means takes place when thrombin and the substrate are contacted in a suitable liquid environment.
REFERENCES:
patent: Re30267 (1980-05-01), Bruschi
patent: 3891507 (1975-06-01), Breuer
patent: 4181500 (1980-01-01), Cowsar et al.
patent: 4234682 (1980-11-01), Bartl et al.
patent: 4390343 (1983-06-01), Walter
patent: 4442204 (1984-04-01), Greenquist et al.
Larsen, et al., Thrombosis Research, vol. 13, No. 2, pp. 285-288.
Greenquist Alfred C.
Sommer Ronald G.
Coe Roger N.
Gzybowski Michael S.
Jeffers Jerome L.
Miles Laboratories Inc.
Richman Barry S.
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