Device and method for the determination of lithium ion...

Chemistry: analytical and immunological testing – Metal or metal containing – Li – na – k – rb – cs – fr – be – mg – ca – sr – ba – ra

Reexamination Certificate

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C422S082050, C422S082060, C422S082070, C422S082080, C422S082090, C436S073000, C436S166000, C436S169000, C436S172000, C540S468000, C540S469000, C540S470000, C540S471000, C549S346000, C549S347000, C549S348000

Reexamination Certificate

active

10776063

ABSTRACT:
The present invention relates to a novel device and method for the detection of lithium ions in a biological fluid. In a preferred embodiment, the present invention provides a novel compound and a optical sensor which incorporates said compound for the detection of lithium ions. Additionally, the present invention provides a method of detecting lithium ions which comprises placing the novel optical sensor into communication with a biological fluid. Once the novel compound of the present invention encounters a lithium ion(s), a fluorescence is generated, the intensity of which is measured and allows for the determination of lithium ion concentration. The present invention provides a medical professional with the ability to selectively determine lithium ion concentration in a biological fluid thereby facilitating the treatment of various diseases, such as manic-depressive illness.

REFERENCES:
patent: 4659815 (1987-04-01), Pacey et al.
patent: 5599913 (1997-02-01), Harris et al.
patent: 5641684 (1997-06-01), Moore et al.
patent: 5926687 (1999-07-01), Dozol et al.
patent: 6417005 (2002-07-01), Barnard et al.
patent: 6660526 (2003-12-01), Benco et al.
patent: 2003/0119195 (2003-06-01), Benco et al.
patent: 2003/0159948 (2003-08-01), Benco et al.
patent: 97/39337 (1997-10-01), None
de Silva, A. P. et al, Journal of the Chemical Society, Chemical Communications 1986, 1709-1710.
Kim, J. S. et al, Journal of Organic Chemistry 2000, 65, 2386-2392.
Kim, J. S. et al, Journal of Organic Chemistry 2002, 67, 2348-2351.
Sabbatini, N. et al, Inorganica Chimica Acta 1996, 252, 19-24, no month.
Chen, Y. et al, Synthetic Communications 1999, 29, 705-711, no month.
Kim, J. S. et al, Journal of Organic Chemistry 2000, 65, 2386-2392, no month.
Marchand, A. P. et al, Tetrahedron 2000, 56, 3121-3126, no month.
Chen, Y. et al, Tetrahedron Letters 2000, 41, 4815-4818, no month.
Sienko M. J. et al, “Chemical Principles and Properties” 1974, pp. 769-770, McGraw-Hill , Inc.: New York, New York.
Yang, F. et al, Supramolecular Chemistry 2001, 12, 445-450.
Benco, J. S. et al, Sensors and Actuators B 2002, 85, 126-130.
Benco, J. S. et al, Journal of Photochemistry and Photobiology, A: Chemistry 2004, 162, 289-296.
Arduini et al., “Calix[4]arenes Blocked in a Rigid Cone Conformation by Selective Functionalization at the Lower Rim”, J. Org. Chem., 1995, v 60, p. 1454-1457.
Benco et al., “A Fluoroionophore for Detection of Potassium ions: 9-anthryl-substituted Azacrown Ether Covalently Linked to a 1,3-alternate Calix[4]arene”, J. of Photochemistry and Photobiology A: Chemistry, 2002, v 152 p. 33-40.
Krause et al., “Emulsion-Based Fluorosensors for Potassium Featuring Improved Stability and Signal Change”, Anal. Chem., 1999, v 71, p. 5304-5308.
McCarrick et al., “Chromogenic Ligands for Lithium Based on Calix[4]arene Tetraesters Bearing Nitrophenol Residues”, J. Chem. Soc. Perkin Trans. 2, 1993, p. 1963-1968.
Prasanna de Silva et al., “Signaling Recognition Events with Fluorescent Sensors and Switches”, Chem. Rev., 1997, v 97, p. 1515-1566.
Rehm et al., “Kinetics of Fluorescence Quenching by Electron and H-Atom Transfer”, Israel Journal of Chemistry, 1979, v 8, p. 259-271.
Valeur, Bernard, “Fluorescent Molecular Sensors of Ions and Molecules”, Molecular Fluorescence: Principles and Applications, 2001, p. 273-314.
Weller, Albert, “Photoinduced Electron Transfer in Solution: Exciplex and Radical Ion Pair Formation Free Enthalpies and their Solvent Dependence”, 1982, p. 93-98.

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