Chemistry: analytical and immunological testing – Including sample preparation – Liberation or purification of sample or separation of...
Patent
1998-01-05
1999-12-21
Soderquist, Arlen
Chemistry: analytical and immunological testing
Including sample preparation
Liberation or purification of sample or separation of...
436178, 436163, 436164, 422 58, 422 81, 422 99, 422100, 422101, 422103, G01N 110, G01N 3100
Patent
active
060048220
ABSTRACT:
Described is a device and method for facilitating the determination of the solubility and dissolution properties of chemical compounds in various solvents. The device uses submilliliter quantities of a solvent and correspondingly small amounts of the chemical compound. The device enables solubility measurements to be made on small amounts of chemical compounds, and enables multiple sampling for generating dissolution profiles. The device includes a housing having first chamber in fluid communication with a second chamber. A pump is provided to force alternatingly the solvent from one chamber to another. A filter located between, and in fluid communication with, the first and second chambers allows flow of a solution of the solvent and the chemical compound between the chambers, and the filter prevents the passage of undissolved compound. The device may also be used for titration studies of submilliliter quantities of solutions or suspensions.
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Anderson Bradley D.
Li Jianmin
LaGreca Alfred
Soderquist Arlen
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