Surgery – Instruments – Light application
Reexamination Certificate
2007-08-21
2007-08-21
Johnson, III, Henry M (Department: 3739)
Surgery
Instruments
Light application
C128S898000, C600S504000, C606S001000
Reexamination Certificate
active
10538548
ABSTRACT:
Ultrashort laser pulses are used to induce photodisruptive breakdown in vasculature in an animal to controllably produce hemorrhage, thrombosis or breach of the blood-brain barrier in individual, specifically-targeted blood vessels. Damage is limited to the targeted vessels such that neighboring vessels exhibit no signs of vascular damage, including vessels directly above and directly below the targeted vessel. Ultrashort laser pulses of lower energy are also used to observe and quantify the baseline and altered states of blood flow. Observation and measurement may be performed by TPLSM, OCT or other known techniques, providing a real-time, in vivo model for the dynamics and effects of vascular injury.
REFERENCES:
patent: 5034613 (1991-07-01), Denk et al.
patent: 5785704 (1998-07-01), Bille et al.
patent: 5796477 (1998-08-01), Teich et al.
patent: 5862287 (1999-01-01), Stock et al.
patent: 6020591 (2000-02-01), Harter et al.
patent: 6154310 (2000-11-01), Galvanauskas et al.
patent: 6156030 (2000-12-01), Neev
patent: 6166385 (2000-12-01), Webb et al.
patent: 6208886 (2001-03-01), Alfano et al.
patent: 6249630 (2001-06-01), Stock et al.
patent: 6325792 (2001-12-01), Swinger et al.
patent: 6351663 (2002-02-01), Flower et al.
patent: 6445491 (2002-09-01), Sucha et al.
patent: 6482199 (2002-11-01), Neev
patent: 6997923 (2006-02-01), Anderson et al.
patent: 2001/0045523 (2001-11-01), Baer
patent: 2001/0053878 (2001-12-01), Ferris et al.
patent: 2002/0034199 (2002-03-01), Galvanauskas et al.
patent: 2005/0035305 (2005-02-01), Kleinfeld et al.
patent: WO 03/060477 (2003-07-01), None
Mitra, P., et al., “Analysis of Dynamic Optical Imaging Data”,Imaging Neurons: A Laboratory Manual(R. Yuste, et al., editors), 1999, pp. 9.1-9.9, Cold Spring Harbor Laboratory Press.
Kleinfeld, D., et al., “Two-photon Imaging of Neocortical Microcirculation”,Imaging Neurons: A Laboratory Manual(R. Yuste, et al., editors), 1999, pp. 23.1-23.15, Cold Spring Harbor Laboratory Press.
Tsai, P., et al., “All-optical, in-situ histology of neuronal tissue with femtosecond laser pulses”,Imaging In Neuroscience and Development: A Laboratory Manual(R. Yuste, et al., editors), 2005, 102:815-826, Cold Spring Harbor Laboratory Press.
Kleinfeld, D., et al., “Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex”,Proc, Natl. Acad. Sci. USA, Dec. 1998, pp. 15741-15746, vol. 95, Neurobiology.
Fujimoto, J., “Optical coherence tomography for ultrahigh resolution in vivo imaging”,Nature Biotechnology, vol. 21, No. 11, Nov. 2003, pp. 1361-1367.
Xie, T., et al., “High-speed optical coherence tomography using fiberoptic acousto-optic phase modulation”,Optics Express, Dec. 1, 2003, pp. 3210-3219, vol. 11, No. 24.
Potter, S., “Vital imaging: Two photons are better than one”,Current Biology1996, vol. 6, No. 12:1595-1598.
Iyer, V., et al., “A compact two-photon laser-scanning microscope made from minimally modified commercial components”,Proceedings of SPIE—Multiphoton Microscopy in the Biomedical Sciences II, A. Periasamy & P.T.C. So, Eds., Jun. 2002, pp. 274-280, vol. 4620.
Mainen, Z. F., et al., “Two-Photon Imaging in Living Brain Slices”,Methods: A Companion to Methods in Enzymology, 1999, pp. 231-239, vol. 18.
Tsai, P.S. et al., “Principles, Design and Construction of a Two-Photon Laser-Scanning Microscope for In Vitro and In Vivo Brain Imaging”, pp. 113-171, Ch. 6 ofIn Vivo Optical Imaging of Brain Function, R.D. Frostig, Ed., 2002, CRC Press.
Tsai, P.S., at al., “All-Optical Histology Using Ultrashort Laser Pulses”,Neuron, Jul. 3, 2003, pp. 27-41, vol. 39.
Friedman Beth
Kleinfeld David
Lyden Patrick D.
Nishimura Nozomi
Schaffer Christopher B.
Johnson, III Henry M
Musick Eleanor M.
Procopio Cory Hargreaves & Savitch LLP
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