Chemistry: molecular biology and microbiology – Apparatus – Including measuring or testing
Reexamination Certificate
2004-06-09
2011-10-25
Beisner, William H (Department: 1775)
Chemistry: molecular biology and microbiology
Apparatus
Including measuring or testing
C435S287200, C422S082000, C422S503000, C422S130000, C436S053000, C366SDIG003, C366SDIG003
Reexamination Certificate
active
08043846
ABSTRACT:
The invention features devices for mixing fluids, e.g., for lysing cells, and methods of use thereof. One device is based on the ability to control the flow of fluids, e.g., by contact angle and channel size. Fluids in this device can be divided to form segments of controlled volume, which are then brought together to initiate mixing. An exemplary use of the device is for the lysis of single cells. Another device is based on the ability to two mix two fluids in a channel and affinity capture of analytes. The devices can be integrated on the same chip with other devices, for example, for cell handling or analysis of DNA, mRNA, and proteins released from the lysis of a cell.
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International Search Report mailed in International Application No. PCT/US04/18370 on Feb. 14, 2005.
Written Opinion mailed in International Application No. PCT/US04/18370 on Feb. 14, 2005.
International Preliminary Report on Patentability issued in International Application No. PCT/US04/18370 on Dec. 13, 2005.
Irimia Daniel
Toner Mehmet
Beisner William H
Fish & Richardson P.C.
The General Hospital Corporation
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