Chemistry: analytical and immunological testing – Automated chemical analysis – Utilizing a centrifuge or compartmented rotor
Patent
1987-04-08
1989-07-11
Marcus, Michael S.
Chemistry: analytical and immunological testing
Automated chemical analysis
Utilizing a centrifuge or compartmented rotor
422 72, 422101, 422102, 436 63, 436177, 494 16, B04B 502, B04B 1100, B01D 2126
Patent
active
048472050
ABSTRACT:
A device and a method for automated processing and separation of an unmeasured sample of whole blood into multiple aliquots of plasma. Capillaries are radially oriented on a rotor, with the rotor defining a sample chamber, transfer channels, overflow chamber, overflow channel, vent channel, cell chambers, and processing chambers. A sample of whole blood is placed in the sample chamber, and when the rotor is rotated, the blood moves outward through the transfer channels to the processing chambers where the blood is centrifugally separated into a solid cellular component and a liquid plasma component. When the rotor speed is decreased, the plasma component backfills the capillaries resulting in uniform aliquots of plasma which may be used for subsequent analytical procedures.
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Burtis et al., "Development of a Simple Device for Processing Whole-Blood Samples . . . ", 32 Clinical Chem. 1672 (1986).
Burtis Carl A.
Johnson Wayne F.
Marcus Michael S.
Martin Marietta Energy Systems Inc.
Spicer James M.
Winchell Bruce M.
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