Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...
Patent
1994-11-08
1997-02-04
Valentine, Donald R.
Chemistry: electrical and wave energy
Processes and products
Electrophoresis or electro-osmosis processes and electrolyte...
204601, G01N 2726, G01N 27447
Patent
active
055994326
ABSTRACT:
A device for the electrophoretic separation of complex fluid substance mixtures comprises a channel system (21, 2, 22) for a carrier medium (C), an injection device (3) for the injection into the carrier medium (C) of a substance mixture (S) to be separated, and a separating path (2) for the separation of the substance mixture (S) in an electric field applied along the separating path (2). Downstream of the injection device (3) for the substance mixture (S) to be separated and at a distance therefrom there is provided a second separating path (4) for the further separation of the substance mixture (S) in an electric field applied along the second separating path (4). The second separating path (4) is inclined at an angle (.alpha.) with respect to the first separating path (2). The region of intersection of the first (2) and second (4) separating paths forms a second injection device (5) for injecting the partially separated substance mixture (S) into a second carrier medium (E). The fluid substance mixture (S) is injected into the carrier medium (C) in the first injection device (3) and is then separated in the electric field that is applied along the first separating path (2). The partially separated substance mixture (S) is then injected into the second carrier medium (E) downstream of the first separating path (2) and further separated into its components in the electric field applied along the second separating path (4).
REFERENCES:
patent: 4385974 (1983-05-01), Shevitz
patent: 4908112 (1990-03-01), Pace
patent: 5131998 (1992-07-01), Jorgenson et al.
patent: 5240577 (1993-08-01), Jorgenson et al.
patent: 5296114 (1994-03-01), Manz
patent: 5328578 (1994-07-01), Gordon
patent: 5389221 (1995-02-01), Jorgenson et al.
X. Huang et al, Anal. Chem. vol. 64, 1992 No Month Available pp. 967-972.
A. T. Andrews, Oxford Science Publications, Monographs on Physical Biochemistry, (1981) No Month Available pp. 222-231.
Journal of Chromatography Library vol. 52 S.F.Y. Li, (1993) No Month Available pp. 172-199 and Contents.
A. V. Lemmee et al. 266b Analy. Chem. 65 (1993) No Month Available No. 11 pp. 1577-1581.
N. Burggraf et al. HRC Jour. of High Resolution Chromatography 16, 1993 No Month Available, No. 10 pp. 594-596.
C. Effenhauser et al. Analy. Chem., 65, (1993) No Month Available No. 19 pp. 2637-2642.
James W. Jorgenson et al "Two-dimensional Separations of Peptides and Proteins by Comprehensive Liquid Chromatography-Capillary Electrophoresis" Electrophoresis, vol. 14, No. 5-6 (May/Jun. 1993) 439-447.
James W. Jorgenson et al "Automated Instrumentation for Comprehensive Two-Dimensional High-Performance Liquid Chromatography/Capillary Zone Electrophoresis" Analytical Chemistry, vol. 62, No. 10 (May 1990) 978-984.
James W. Jorgenson et al, "Two-Dimensional Protein Separation by Microcolumn Size-Exlusion Chromatography-Capillary Zone Electrophoresis" Journal of Chromatography (Feb. 1993) 213-220.
D. Kaniansky et al "Capillary Zone Electrophoresis of Complex Ionic Mixtures with On-Line Isotachophoretic Sample Pretreatment" Journal of Chromatography, 638 (May 1933) 137-146.
U. R. Tjaden et al, "Analyte Focusing in Capillary Electrophoresis Using On-Line Isotachophoresis" Journal of Chromatography, 591 (Feb. 1992) 341-349.
Effenhauser Carlo S.
Manz Andreas
Ciba-Geigy Corporation
Dohmann George R.
Starsiak Jr. John S.
Valentine Donald R.
LandOfFree
Device and a method for the electrophoretic separation of fluid does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Device and a method for the electrophoretic separation of fluid , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Device and a method for the electrophoretic separation of fluid will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-675161