Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1996-06-05
1999-03-02
Spector, Lorraine
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530402, 530300, 530383, 435 697, 536 231, 536 234, 536 235, C07K 14435, C07K 14485, C07K 14755, C12N 1511
Patent
active
058772812
ABSTRACT:
The present invention relates to a member of a novel gene family referred to as developmentally-regulated endothelial cell locus-1 (del-1). In particular, the invention relates to del-1 nucleotide sequences, Del-1 amino acid sequences, methods of expressing a functional gene product, and methods of using the gene and gene product.
REFERENCES:
patent: 4868112 (1989-09-01), Toole, Jr. et al.
patent: 5096825 (1992-03-01), Barr et al.
patent: 5270170 (1993-12-01), Schatz et al.
patent: 5505955 (1996-04-01), Peterson et al.
patent: 5506107 (1996-04-01), Cunningham et al.
Anderson, 1990, "Adhesion molecules and animal development," Experientia 46:2-13.
Brooks et al., 1994, "Integrin .alpha..sub.v .beta..sub.3 Antagonists Promote Tumor Regression by Inducing Apoptosis of Angiogenic Blood Vessels," Cell 79:1157-1164.
Couso and Arias, 1994, "Notch is Required for wingless Signaling in the Epidermis of Drosophila," Cell 79:259-272.
Crowley et al., 1985, "Phenocopy of Discoidin I-Minus Mutants by Antisense Transformation in Dictyostelium," Cell 43:633-641.
Fortini and Artavanis-Tsakonas, 1994, "The Suppressor of Hairless Protein Participates in Notch Receptor Signaling," Cell 79:273-282.
Fukuzawa and Ochiai, 1988, "Monoclonal Antibodies against Discoidin I and Discoidin II of the Cellular Slime Mold, Dictyostelium discoideum," J. Biochem 103:884-888.
Henderson et al., 1994, "lag-2 may encode a signaling ligand for the GLP-1 and LIN-12 receptors of C. elegans," Development 120:2913-2924.
Hynes, 1992, "Integrins: Versatility, Modulation, and Signaling in Cell Adhesion," Cell 69:11-25.
Johnson et al., 1993, "A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain," Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681.
Kane and Davie, 1986, "Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin," Proc. Natl. Acad. Sci. U.S.A. 83:6800-6804.
Kronmiller et al., 1991, "EGF Antisense Oligodeoxynucleotides Block Murine Odontogenesis in Vitro," Dev. Biol. 147:485-488.
Larocca et al., 1991, "A M, 46,000 Human Milk Fat Globule Protein That Is Highly Expressed in Human Breast Tumors Contains Factor VIII-like Domains," Cancer Res. 51:4994-4998.
Main et al., 1992, "The Three-Dimensional Structure of the Tenth Type III Module of Fibronectin: An Insight into RGD-Mediated Interactions," Cell 71:671-678.
Orsini et al., 1991, "Radioimmunoassay of Epidermal Growth Factor in Human Saliva and Gastric Juice," Clinical Biochem. 24:135-141.
Rebay et al., 1991, "Specific EGF Repeats of Notch Mediate Interactions with Delta and Serrate: Implications for Notch as a Multifunctional Receptor," Cell 67:687-699.
Stubbs et al., 1990, "cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences," Proc. Natl. Acad. Sci. U.S.A. 87:8417-8421.
Dumont et al., The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors, Oncogene, 8(5): 1293-1301, May 1993.
Hogan Brigid
Quertermous Thomas
Snodgrass H. Ralph
Zupancic Thomas Joel
Kaufman Claire M.
Progenitor, Inc.
Spector Lorraine
Vanderbilt University
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