Developmental animal model of temporal lobe epilepsy

Details Developmental animal model of temporal lobe epilepsy Developmental animal model of temporal lobe epilepsy

2006-04-06

2009-11-24

Hama, Joanne (Department: 1632)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Reexamination Certificate

active

07622101

ABSTRACT:
Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily administration of low doses of a kainate receptor agonist to the animal in the second postnatal week, wherein after treatment with the kainate receptor agonist the animal exhibits reproducible seizure-like symptoms when exposed to mild to moderate stressors. Rats treated using the above method are particularly useful as a non-human system for studying temporal lobe epilepsy, as well as for studying the efficacy of potential anti-epileptic compounds and pharmaceutical preparations.

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Anne Bernard, Lotfi Ferhat, Fréd

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