Multicellular living organisms and unmodified parts thereof and – Nonhuman animal – The nonhuman animal is a model for human disease
Reexamination Certificate
2006-04-25
2006-04-25
Nguyen, Dave Trong (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Nonhuman animal
The nonhuman animal is a model for human disease
C800S014000
Reexamination Certificate
active
07034201
ABSTRACT:
Disclosed is a developmental animal model of temporal lobe epilepsy and other seizure-related disorders. In particular, the invention provides a method of inducing a permanent change in the neurological development of a rodent, such as a rat, comprising daily administration of low doses of a kainate receptor agonist to the animal in the second postnatal week, wherein after treatment with the kainate receptor agonist the animal exhibits reproducible seizure-like symptoms when exposed to mild to moderate stressors. Rats treated using the above method are particularly useful as a non-human system for studying temporal lobe epilepsy, as well as for studying the efficacy of potential anti-epileptic compounds and pharmaceutical preparations.
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Philip J. Larsen, Jens D. Mikkelsen, David S. Jess
Bak-Jensen Henriette Husum
Doucette Tracy
Perry Melissa
Ryan Catherine
Tasker R. Andrew
Emch, Schaffer, Schaub & Porcello & Co., L.P.A.
Hama Joanne
Nguyen Dave Trong
University of Prince Edward Island
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