Development of molecular imaging probes for carbonic...

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...

Reexamination Certificate

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C549S032000

Reexamination Certificate

active

07829063

ABSTRACT:
The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.

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Wilkinson Brendan L. et al.: “A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by “click-tailing”.”, Journal of Medicinal Chemistry, Nov. 2, 2006, vol. 49, No. 22, Nov. 2, 2006, pp. 6539-6548, XP002496737, ISSN: 0022-2623, p. 6539, left-hand column; figure 2; compounds 2,3, p. 6540, left-hand column, paragraph 1.
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International Search Report in Application No. PCT/US2009/003309 dated Nov. 12, 2009.

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