Development of a simple animal model for infection by...

Details Development of a simple animal model for infection by... Development of a simple animal model for infection by...

2011-04-26

2011-04-26

Chen, Stacy B (Department: 1648)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S021000, C424S204100

Reexamination Certificate

active

07932430

ABSTRACT:
The present invention provides methods for studying pathogenesis of mammalian viruses. In particular, the present invention provides a nonhuman animal model system for studying disease mechanisms wherein the nonhuman animal model is infected with an animal virus. In a preferred embodiment the animal model isC. elegansand the animal virus is vesicular stomatitis virus (VSV).

REFERENCES:
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Garsin et al. 2001. A simple model for identifying Gram positive virulence factors. Proceedings in National Academy of Science. 98:10892-97.
Kim et al. 2002. A conserved p38 Map kinase pathway inCaenorhabditis elegansinnate immunity. Science. 297:623-26.
Labrousse et al. 2000.C. elegansis a model host forSalmonella typhimurium. Current Biology. 10:1543-45.
Mahajan-Miklos et al. 1999. Molecular mechanisms of bacteria virulence elucidated using aP. aeruginosa—C. eleganspathogenesis model. Cell 96:47-56.
Pujol et al. 2001. A reverse genetic analysis of components of the Toll signaling pathway inC. elegans. Current Biology. 11:809-21.
Tan et al. 1999.P. aeruginosakillingC. elegansused to identifyP. aeruginosavirulence factors. Proceedings in National Academy of Science. 96:2408-13.

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