Deuterated sevoflurane as an inhalational anesthetic

Details Deuterated sevoflurane as an inhalational anesthetic Deuterated sevoflurane as an inhalational anesthetic

1993-06-14

1995-02-21

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ether doai

A61K 3108

Patent

active

053915798

ABSTRACT:
Use of D2-sevoflurane is disclosed as an inhalational anesthetic. Deuterated sevoflurane possess all of the desirable qualities of sevoflurane as an anesthetic and is metabolized more slowly thereby reducing potentially toxic inorganic fluoride release. More particularly, the compound fluorodideutero methyl 1,1,1,3,3,3-hexafluoropropyl ether is disclosed as well as a method for synthesis.

REFERENCES:
patent: 3346448 (1967-10-01), Gilbert
patent: 3476860 (1969-11-01), Croix
patent: 3683092 (1972-08-01), Regen
patent: 3883665 (1975-05-01), Croix
patent: 4069346 (1978-01-01), McCarty
patent: 4142525 (1979-05-01), McCarty
patent: 4154971 (1979-05-01), Larsen
patent: 4188405 (1980-02-01), Larsen
patent: 4250334 (1981-02-01), Coon
patent: 4328376 (1982-05-01), Berger
patent: 4874902 (1989-10-01), Huang
patent: 4996371 (1991-02-01), Halpern
McCarty, American Society of Anesthesiologists, 51:106-110 (1979).
Holaday, American Society of Anesthesiologists, 57:3 (Sep. 1982).
Chemical Abstracts 92:197928n, vol. 92, p. 639 (1980).
Chemical Abstracts, 91:56377m, vol. 91, p. 647 (1979).
Chemical Abstracts, 88:14705n p. 339 (1978).
Chemical Abstracts, 90:105792w vol. 90, p. 107 (1979).
Chemical Abstracts 94:102829k (1981).
Chemical Abstracts 91:140334r (1979).
Holaday et al., Deuteration Reduced Significantly the Biotransformation of Sevoflurane, Am. Soc. of Anesthesiologists, Inc., 57:3 Sep. 1982.

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