Deuterated sevoflurane as an inhalational anesthetic

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ether doai

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A61V 3108

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active

057894507

ABSTRACT:
Use of D2-sevoflurane is disclosed as an inhalational anesthetic. Deuterated sevoflurane possess all of the desirable qualities of sevoflurane as an anesthetic and is metabolized more slowly thereby reducing potentially toxic inorganic fluoride release. More particularly, the compound fluorodideutero methyl 1,1,1,3,3,3-hexafluoropropyl ether is disclosed as well as a method for synthesis.

REFERENCES:
Holaday et al., Deuteration Reduced Significantly the Biotransformation of Sevoflurane, Am Soc. of Anesthesiologist, Inc. 57:3 Sep. 1982.

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