Deuterated prostaglandin analogs

Details Deuterated prostaglandin analogs Deuterated prostaglandin analogs

1975-03-03

1977-01-11

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603457, 2604488R, 260514D, 424305, 424317, C07C17700

Patent

active

040026639

ABSTRACT:
Deuterated analogs of prostaglandins have been prepared and found to display increased activity as antifertility, bronchodilator and/or bronchoconstrictor agents compared to the natural prostaglandins. The analogs are conveniently prepared by reduction of the 15-keto group and/or the 9-keto group with a deuterated reducing agent.

REFERENCES:
patent: 3903143 (1975-09-01), Mueller
Hamberg et al., J.B.C., 246, 1073 (1971).

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