Deuterated analogs of 1,25-dihydroxycholecalciferol

Details Deuterated analogs of 1,25-dihydroxycholecalciferol Deuterated analogs of 1,25-dihydroxycholecalciferol

1987-09-14

1990-02-06

Konopka, Paul E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

2603972, 556436, 560119, 568374, 568819, A61K 3159, C07J 900

Patent

active

048988553

ABSTRACT:
The invention is directed to deuterated vitamin D analogs, and processes and intermediates for their preparation. The end products, that is the deuterated vitamin D analogs, are useful for the treatment osteoporosis and cutaneous inflammations such as psoriasis, and contact dermatitis.

REFERENCES:
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patent: 4424161 (1984-01-01), Holick
patent: 4508651 (1985-04-01), Baggiolini et al.
patent: 4804502 (1989-02-01), Baggiolini et al.
Chemical Abstracts, vol. 90, no. 3, Jan. 15, 1979, 17948 W.
American Chemical Society, vol. 18, No. 18, 1979, pp. 3977-3983, Esvelt et al.
FEBS Letters, vol. 94, No. 2, Oct. 1978, pp. 228-230, Redel et al.
American Chemical Society, vol. 18, No. 22, 1979, pp. 4775-4780, Wichmann et al.

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