Deubiquitinating enzyme: compositions and methods

Details Deubiquitinating enzyme: compositions and methods Deubiquitinating enzyme: compositions and methods

1993-11-24

1996-10-15

Wax, Robert A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352523, 435201, 43525411, 4352542, 43525421, 4352552, 4352551, 4353201, 4351723, 536 232, 935 69, 935 10, 935 14, C12N 1553, C12N 119, C12N 118, C12N 116, C12N 121, C12N 510, C12N 1563

Patent

active

055653529

ABSTRACT:
The invention relates generally to compositions of and methods for obtaining deubiquitinating enzyme polypeptides. The invention relates as well to polynucleotides encoding deubiquitinating enzyme polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant deubiquitinating enzyme polypeptides. By way of example, the invention discloses the cloning and functional expression if at least three different deubiquitinating enzyme polypeptides. The invention includes as well, methods for using the isolated, recombinant enzyme polypeptides in assays designed to select and improve substances capable of interacting with deubiquitinating enzyme polypeptides for use in diagnostic, drug design and therapeutic applications.

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