Detomidine hydrochloride crystallization method

Details Detomidine hydrochloride crystallization method Detomidine hydrochloride crystallization method

2006-04-13

2010-06-01

Saeed, Kamal A (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07728147

ABSTRACT:
A method of isolating detomidine (I) hydrochloride as a crystalline salt is provided. The method comprises hydrogenating in the presence of a catalyst of compound of formula (II) in aqueous solution comprising hydrochloric acid, concentrating the solution by distillation, optionally adding hydrochloric acid to the concentrated solution, cooling the concentrated solution and recovering the crystallized detomidine hydrochloride. The product can be recovered directly from aqueous solution with

REFERENCES:
patent: 4584383 (1986-04-01), Parhi
Davey, DD. et al. “Convenient Synthesis of 4-methylhistamine and racemic alpha, 4-dimethylhistamine and alpha, 4-dimethylhistidine,”Journal of Organic Chemistry(1989) 54(13):3211-3213.
International Search Report mailed Aug. 4, 2006, for International Application No. PCT/FI2006/000113.
Written Opinion mailed Jul. 4, 2006, for International Application No. PCT/FI2006/000113.

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