Determining the concentration of water soluble species in biolog

Details Determining the concentration of water soluble species in biolog Determining the concentration of water soluble species in biolog

1989-09-18

1991-03-19

Warden, Robert J.

Chemistry: analytical and immunological testing

Biological cellular material tested

436 23, 436 68, 436 71, 436 74, 436 79, 436 86, 436 95, 436148, 436179, 73 611R, G01N 2700, G01N 3300, G01N 3700

Patent

active

050010670

ABSTRACT:
Correcting an initial measurement of the concentration of a first water soluble species dissolved in a water-based component of a biological fluid that also includes a second water soluble species and a volume occupying component, the initial measurement having been taken using an original sample of the fluid that had been diluted by an amount of additional aqueous solution to form a diluted sample is disclosed; the concentration of the second water soluble species is measured in an undiluted sample of the biological fluid to obtain a direct concentration and is measured using a diluted sample of the fluid to obtain an indirect concentration, and the initial measurement of concentration of the first species is adjusted based on a combination of the direct and indirect concentration determinations of the second species.

REFERENCES:
Shyr et al., "Effect of Sample Protein Concentration on Results of Analyses for Sodium and Potassium in Serum," Clin. Chem. 26: 1517 (1980).
Coleman et al., "Evidence for Formation of Bicarbonate Complexes with N.sup.a and K.sup.+ Under Physiological Conditions, " Clin. Chem. 27: 1938-1939 (1981).
Flannery, "Differences in Electrolyte Results as Measured by Direct Potentiometry (Ion Selective Electrode) and Flame Photometry." Technical Bulletin, Nova Biomedical.

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