Determining pregnancy induced hypertension and eclampsia by immu

Details Determining pregnancy induced hypertension and eclampsia by immu Determining pregnancy induced hypertension and eclampsia by immu

1989-01-27

1992-01-07

Rosen, Sam

Chemistry: analytical and immunological testing

Immunochemical pregnancy determination

436518, 436536, 436 65, 436814, G01N 3353

Patent

active

050791710

ABSTRACT:
Preeclampisa, pregnancy induced hypertension (PIH) and eclampsia are determined by identifying the presence of an endothelial cell marker in a sample of blood, plasma or serum of a pregnant woman using a sandwich or competition immunoassay. Cellular fibronectin marker in a sample is determined by binding with an anti-(cellular fibronectin) antibody. Reagents for these methods are also an aspect of the invention.

REFERENCES:
patent: 4980279 (1990-12-01), Peters et al.
Yamada, K. M., "Fibronectin and Other Structural Proteins", Cell Biology of the Extracellular Matrix, Hay, E. D. (ed.), Plenum Press, pp. 95-97 (1981).
Saleh et al., "Hemostasis in Hypertensive Disorders of Pregnancy", Hemostasis and Hypertension, vol. 71(5), pp. 719-722 (1988).
Ermolin et al., "Quantitative Immunoenzymic Assay of Fibronectin in Biological Fluids", Chemical Abstracts, vol. 106:46781r (1987).
Canavaggio et al., "Measurement of Human Fibronectin by Enzyme Immunoassay Using Monoclonal Antibodies", Chemical Abstracts, vol. 100:47905x (1984).
Wisdom, G. B., "Enzyme-Immunoassay", Clinical Chemistry, vol. 22(8), pp. 1243-1255 (1976).
Gutman, A. et al., Proc. Natl. Acad. Sci. U.S.A. 84:7179-7182 (1987).

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