Determining potency of streptococcal preparations

Details Determining potency of streptococcal preparations Determining potency of streptococcal preparations

1982-12-30

1985-07-16

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 88, 436536, 436538, 436543, A61K 4900, G01N 3348, G01N 3354

Patent

active

045295816

ABSTRACT:
Antigenicity of streptococcal preparations useful for inducing anti-streptococcal immunity in animals can be determined using a combining power technique. Method involves incubating serial dilutions of the antigen preparation with known amounts of anti-streptococcal antiserum, thereby lessening, in serial manner, the combining power of the antiserum. The serial reaction products are then incubated with serial dilutions of streptococcal preparations having known activity and the effects of the serial reaction products on such activity are then determined by in vivo means. Those determinations can be related to a standard for determining potency of the streptococcal preparation. Assay technique is especially useful in determining potency of Streptococcus equi bacterins or bacterin derivatives.

REFERENCES:
patent: 3940475 (1976-02-01), Gross
Maggio, V. Enzyme-Immunoassay, CRC Press Inc., Florida, 1980, pp. 168-170.
Lancefield, J. Exp. Med., 106 (1957) 525-544.
Lancefield, J. Exp. Med., 67 (1938) 25-40.

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