Determining plasmodium in blood by sphingomyelin synthase activi

Details Determining plasmodium in blood by sphingomyelin synthase activi Determining plasmodium in blood by sphingomyelin synthase activi

1995-12-08

1999-11-02

Gitomer, Ralph

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 34, 435184, 5142378, C12Q 100, C12N 999

Patent

active

059767812

ABSTRACT:
Plasmodium is shown to have an inhibition sensitive sphingomyelin synthase activity necessary for ring and early trophozoite maturation. Inhibitors can therefore be used to identify malarial infection which can differentiate between inhibition sensitive Plasmodium sphingomyelin synthase and mammalian synthase. Inhibitors of interest include 1-phenyl-3-morpholino-2-acylated-aminopropanol-1.

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Haldar R., The Accumulation and Metabolism . . . Mol & Biochem Parasit 49 (1991) 143-156.
Vunnam R., Analogs of Ceramide That Inhibit . . . Chem & Physics of Lipids 26 (1980) 265-278.

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