Determining invasiveness of prostatic adenocarcinoma

Details Determining invasiveness of prostatic adenocarcinoma Determining invasiveness of prostatic adenocarcinoma

1995-06-07

1998-11-03

Feisee, Lila

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 71, 435 405, 435 4052, 530386, 5303871, 5303877, C12Q 100, G01N 3353, C07K 1600

Patent

active

058306404

ABSTRACT:
The invention relates to methods for determining metastatic potential of tumors and to methods and compositions for inhibiting or preventing metastasis of cancers. In one aspect, the invention provides a method to determine metastatic potential of tumors, particularly prostatic tumors. In this regard the invention relates to determining protein or mRNA of effectors of arachadonic acid release to gauge metastatic potential, particularly uteroglobin protein or mRNA to determine metastatic potential of prostatic tumors.
The invention also relates to methods and compositions that prevent or inhibit metastasis of cancers. In this regard, the invention particularly relates to methods and compositions that inhibit arachidonic acid, those that inhibit phospholipase A.sub.2. More particularly in this regard, the invention relates to uteroglobin or muteins, peptide analogs or mimetics of uteroglobin and lipocortins or muteins, peptide analogs, or mimetics of lipocortins that inhibit metastasis. Especially it relates to methods and compositions in which uteroglobins, particularly human uteroglobins, inhibit or prevent metastasis of cancer, particularly prostatic cancer.

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