Chemistry: analytical and immunological testing – Oxygen containing – Carbonyl – ether – aldehyde or ketone containing
Reexamination Certificate
2005-07-26
2005-07-26
Gakh, Yelena G. (Department: 1743)
Chemistry: analytical and immunological testing
Oxygen containing
Carbonyl, ether, aldehyde or ketone containing
Reexamination Certificate
active
06921668
ABSTRACT:
A method for determining the presence of an infection in a liquid sample comprising the steps of: lowering the pH of the liquid sample so as to drive short-chain fatty acids present in the liquid sample, acetic acid in particular, to the gaseous phase; detecting short-chain fatty acids, ammonia and, optionally amine species present as gases in a headspace associated with the liquid sample using a detector which is sensitive to the presence of short-chain fatty acids, ammonia and, optionally, amine species, particularly conductive and semi-conductive polymer sensors; and correlating the presence of detected short-chain fatty acids, ammonia and, optionally, amine species with the presence of the infection.
REFERENCES:
patent: 5788687 (1998-08-01), Batich et al.
patent: 6244096 (2001-06-01), Lewis et al.
patent: 95 33848 (1995-12-01), None
patent: 99 66304 (1999-12-01), None
patent: 00 53798 (2000-09-01), None
Bogaard et al. “Quantitative Gas Chromatographic Analysis of Volatile Fatty Acids in Spent Culture Media and Body Fluids”, J Clin. Microbiol., 1986, pp. 523-530.
Molly et al.“Development of a 5-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem”, Appl. Microbiol. Biotechnol., 1993, v. 39, pp. 254-258.
Chandiok et al. “Screening for Bacterial Vaginosis”: a Novel Application of Artificial Nose Technology”, J. Clin. Pathol., 1997, v. 50, No. 9pp. 790-795.
Pavlou et al. “An intelligent rapid odor recognition model in discrimination of Helicobacter pylori and other gastroesophageal isolates in vitro”, Biosens. Bioelectron., 2000, v. 15, pp. 333-342.
Hayward, N.J., et al., “Head-Space/Gas-Liquid Chromatography in Clinical Microbiology with Special Reference to the Laboratory Diagnosis of Urinary Tract Infections,” Gas Chromatography 7 Mass Spectrum. Appl. Microbiol, 1984, pp. 237-255, XP000923009, p. 241, line 1-p. 243, paragraph 2.
Pavlou, A.K., et al., “Sniffing Out the Truth: Clinical diagnosis using the electronic nose,” Clinical Chemistry and Laboratory Medicine, vol. 38, No. 2, Feb. 2000, pp. 99-112, XP001061838, ISSN: 1434 6621, p. 103, right-hand column, paragraph 2, p. 104, left-hand column, paragraph 2, figure 7.
Aathithan, S., et al., “Diagnosis of bacteriuria by detection of volatile organic compounds in urine using an automated headspace analyzer with multiple conducting polymer sensors,” Journal of Clinical Microbiology, vol. 39, No. 7, Jul. 2001, pp. 2590-2593, XP002192447, ISSN: 0095-1137, whole document.
Guernion, Nicolas, et al., “Identifying bacteria in human urine: Current practice and the potential for rapid, near-patient diagnosis by sensing volatile organic compounds,” Clinical Chemistry and Laboratory Medicine, vol. 39, No. 10, Oct. 2001, pp. 893-906, XP 001061839, ISSN: 1434-6621, p. 898, right-hand column, paragraph 2—p. 899, right-hand column, paragraph 3; table 4.
Coloe, P.J., “Ethanol Formed from Arabinose: A Rapid Method for Detecting Escherichia Coli,” Journal of Clinical Pathology, London, GB, vol. 31, 1978, pp. 361-364, XP000922894, ISSN: 0021-9746, abstract.
Haywood, N.J., et a l., “Assessment of Technique for Rapid Detection of Escherichia Coli And Proteus Species in Urine by Head-Space Gas-Liquid Chromatography,” Journal of Clinical Microbiology, Washington, D.C. vol. 6, No. 3, Sep. 1977, pp. 202-208, XP000922891, ISSN: 0095-1137 abstract.
Davies, T. J. and Hayward, N.J., “Volatile Products from Acetylcholine as Markers in the Rapid Urine Test Using Head-Space Gas-Liquid Chromatography,” Journal of Chromatography, vol. 307, 1984, pp. 11-21.
Aiken Sean Sydney
Chaudry Amjad Nissar
Henery Martin James
Manning Janet Elizabeth
McNeish Alexander Samuel
Gakh Yelena G.
Marger & Johnson & McCollom, P.C.
Osmetech PLC
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