Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-08-16
2011-08-16
Goldberg, Jeanine A (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S091200, C435S287100
Reexamination Certificate
active
07998680
ABSTRACT:
The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.
REFERENCES:
patent: 4399216 (1983-08-01), Axel et al.
patent: 4434156 (1984-02-01), Trowbridge
patent: 4511503 (1985-04-01), Olson et al.
patent: 4666927 (1987-05-01), Hider et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4711845 (1987-12-01), Gelfand et al.
patent: 4912118 (1990-03-01), Hider et al.
patent: 5024939 (1991-06-01), Gorman
patent: 5075469 (1991-12-01), Chevion
patent: 5104865 (1992-04-01), Hider et al.
patent: 5116964 (1992-05-01), Capon
patent: 5185368 (1993-02-01), Peter et al.
patent: 5256676 (1993-10-01), Hider et al.
patent: 5304472 (1994-04-01), Bass et al.
patent: 5328992 (1994-07-01), Peter et al.
patent: 5385918 (1995-01-01), Connell et al.
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5420008 (1995-05-01), Nishida et al.
patent: 5424057 (1995-06-01), Peter et al.
patent: 5582979 (1996-12-01), Weber
patent: 5674681 (1997-10-01), Rothenberg et al.
patent: 5705343 (1998-01-01), Drayna et al.
patent: 5712098 (1998-01-01), Tsuchihashi et al.
patent: 5719125 (1998-02-01), Suzuki et al.
patent: 5753438 (1998-05-01), Drayna et al.
patent: 5872237 (1999-02-01), Feder et al.
patent: 6025130 (2000-02-01), Thomas et al.
patent: 6140305 (2000-10-01), Thomas et al.
patent: 6228594 (2001-05-01), Thomas et al.
patent: 6284732 (2001-09-01), Feder et al.
patent: 6355425 (2002-03-01), Rothenberg et al.
patent: 6391852 (2002-05-01), Feder et al.
patent: 6509442 (2003-01-01), Rothenberg et al.
patent: 6955875 (2005-10-01), Rothenberg et al.
patent: 7067255 (2006-06-01), Thomas et al.
patent: 2003/0092019 (2003-05-01), Meyer et al.
patent: 2115221 (1994-08-01), None
patent: 2115222 (1994-08-01), None
patent: 2115224 (1994-08-01), None
patent: 208 609 (1984-04-01), None
patent: 4 327 226 (1995-02-01), None
patent: 0 346 281 (1989-12-01), None
patent: 2 293 269 (1996-03-01), None
patent: WO 92/06180 (1992-04-01), None
patent: WO 93/14188 (1993-07-01), None
patent: WO 93/15609 (1993-08-01), None
patent: WO 93/19768 (1993-10-01), None
patent: WO 93/20221 (1993-10-01), None
patent: WO 94/01463 (1994-01-01), None
patent: WO 94/04186 (1994-03-01), None
patent: WO 94/06922 (1994-03-01), None
patent: WO 94/06923 (1994-03-01), None
patent: WO 94/11367 (1994-05-01), None
patent: WO 94/21243 (1994-09-01), None
patent: WO 95/16663 (1995-06-01), None
patent: WO 96/06583 (1996-03-01), None
patent: WO 96/17870 (1996-06-01), None
patent: WO 96/35802 (1996-11-01), None
Bernard et al. (Am. J. of Pathology, vol. 153, No. 4, pp. 1055-1061, Oct. 1998).
Arya et al. (Blood Cells, Molecules and Disease, vol. 25, No. 22, pp. 354-357, 1999).
Lucentini (The Scientist; 2004, vol. 24, p. 20).
Hirschhorn et al. (Genetics in Medicine. vol. 4, No. 2, pp. 45-61, Mar. 2002).
Ioannidis (Nature Genetics, vol. 29, pp. 306-309, Nov. 2001).
Asberg et al (Genetic Testing, vol. 6, No. 1, pp. 59-62, 2002).
European Search Report from 05005829.6, Apr. 16, 2007, Bio-Rad Laboratories.
Abravaya, K., et al., “Detection of Point Mutations With a Modified Ligase Chain Reaction (Gap-LCR),” Nucl. Acids Res. (1995) 23(4):675-682 (Abbott Laboratories).
Adams, M.D., et al., “Complementary DNA Sequencing: Expressed Sequence Tags and Human Genome Project,” Science (1991) 252:1651-1656 (National Institutes of Health).
Altman, J.D. et al., “Phenotypic Analysis of Antigen-Specific T Lymphocytes,” Science 274:94-96 (1996).
Alvarez et al., “A Point Mutation in the Cytoplasmic Domain of the Transferrin Receptor Inhibits Endocytosis”, Biochem J. (1990): 267: 31-35.
Alvarez et al., “Inhibition of the Receptor-Mediated Endocytosis of Diferric Transferrin Is Assocaited with the Covalent Modification of the Transferrin Receptor with Palmitic Acid” JBC (1990) 265(27):16644-16655.
Amadou, C., et al., “Localization of New Genes and Markers to the Distal Part of the Human Major Histocompatibility Complex (MHC) Region and Comparison With the Mouse: New Insights Into the Evolution of Mammalian Genomes,” Genomics (1995) 26:9-20 (0888-7543/95).
Anderson, G.J. et al., “Transferrin Receptor Distribution and Regulation in the Rat Small Intestine,” Gastroenterology 98:576-585 (1990).
Anderson, J.R., et al., “Precipitating Autoantibodies in Sjögren's Disease,” Lancet (1961) 2:456460 (Glasgow Univ.).
Arteaga, C.L. et al., “Tissue-targeted Antisense c-fos Retroviral Vector Inhibits Established Breast Cancer Xenografts in Nude Mice,” Canc. Res. 56:10981103 (1996).
Bacon, B.R., “Causes of Iron Overload,” N. Engl. J. Med. (1992) 326(2):126-127 (St. Louis Univ. School of Medicine).
Balan, V., et al., “Screening fro Hemochromatosis: A Cost-Effectiveness Study Based on 12,258 Patients,” Gastroenterology (1994) 107:453-459 (0016-5085/94).
Banerjee, D. et al., “Transferrin Receptors in the Human Gastrointestinal Tract,” Gastroenterology 91:861-869 (1986).
Barany, F., “Genetic Disease Detection and DNA Amplification Using Cloned Thermostable Ligase,” Proc. Natl. Acad. Sci. USA (1991) 88:189-193 (National Institutes of Health).
Barton, J.C., et al., “Blood Lead Concentrations in Hereditary Hemochromatosis,” J. Lab. Clin. Med. (1994) 124(2):193-198 (0022-2143/94).
Barton, J.C., et al., “Hemochromatosis: The Genetic Disorder of the Twenty-First Century,” Nature Medicine (1996) 2(4):394-395 (Brookwood Medical Center).
Beaucage, S.L., et al., “Deoxynucleoside Phosphoramidites-A New Class of Key Intermediates for Deoxypolynucleotide Synthesis,” Tetrahedron Letters (1981) 22(20):1859-1862 (0040-4039/81).
Beggs, J.D., “Transformation of Yeast by a Replicating Hybrid Plasmid,” Nature (1978) 275:104-109 (0028-0836/78).
Benton, W.D., et al., “Screening λgt Recombinant Clones by Hybridization to Single Plaques in situ,” Science (1977) 196:180-182 (National Institutes of Health).
Beutler, E. et al., “Mutation Analysis in Hereditary Hemochromatosis” Blood Cells, Molecules, and Diseases (1996), 22(16): 187-194.
Beutler, E., et al., “A Strategy for Cloning the Hereditary Hemochromatosis Gene,” Blood Cells, Molecules, and Diseases (1995) 21(21):207-216 (1079-9796/95).
Bjorkman, P.J., et al., “Structure, Function, and Diversity of Class I Major Histocompatibility Complex Molecules,” Annu. Rev. Biochem. (1990) 59:253-288 (0066-4154/90).
Boretto, J., et al., “Anonymous Markers Located on Chromosome 6 in the HLA-A Class I Region: Allelic Distribution in Genetic Haemochromatosis,” Hum. Genet. (1992) 89:33-36 (Institut National de la Sante et de la Recherche Medicale).
Botstein, D., et al., “Sterile Host Yeasts (SHY): A Eukaryotic System of Biological Containment for Recombinant DNA Experiments,” Gene (1979) 8:17-24 (American Cancer Society).
Brent, R. et al., “A bacterial repressor protein or a yeast transcriptional terminator can block upstream activation of a yeast gene,” Nature 312:612-615 (1984).
Brent, R. et al., “A Eukaryotic Transcriptional Activator Bearing the DNA Specificity of a Prokaryotic Repressor,” Cell 43:729-736 (1985).
Broach, J.R., et al., “Transformation in Yeast: Development of a Hybrid Cloning Vector and Isolation of the CANI Gene,” Gene (1979) 8:121-133 (National Institutes of Health).
Calandro, L.M., et al., “Characterization of a Reco
Drayna Dennis T.
Feder John N.
Gnirke Andreas
Ruddy David
Thomas Winston J.
Bio-Rad Laboratories, Inc.
Goldberg Jeanine A
Jones Day
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