Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-01-18
2008-08-05
Bausch, Sarae (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C435S091200
Reexamination Certificate
active
07407755
ABSTRACT:
The present invention relates to methods and kits for determining a predisposition and surveillance protocols for developing cancer of various sites due to specific mutation in at least one allele of CHEK2 gene and/or at least one allele of NOD2 gene and/or at least one allele of CDKN2A gene.
REFERENCES:
patent: 2002/0004206 (2002-01-01), Berger et al.
Dong et al. Mutations in CHEK2 Associated with Prostate Cancer Risk. 2003. American Journal of Human Genetics. vol. 72 pp. 270-280.
Bell et al. Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome. 1999. Science. vol. 286 pp. 2528-2531.
Dufault et al. Limited Relevance of the CHEK2 gene in hereditaty breast cancer. International Journal of Cancer. vol. 110 pp. 320-325.
Ingvarsson et al. Mutation analysis of the CHK2 gene in breast carcinoma and other cancers. 2002. Breast Cancer Research. vol. 4 pp. 1-6.
Verhagen, Arianne. Is the ρ value really so significant. 2004. Australian Journal of Physiotherapy vol. 50 pp. 261-262.
Dufault, Michael et al. Limited Relevance of the CHEK2 gene in hereditary breast cancer. 2004. International Journal of Cancer. vol. 110 pp. 320-325.
Cybulski Cezary
Dêbniak Tadeusz
Kurzawski Grzegorz
Lubiñski Jan
Suchy Janina
Bausch Sarae
Cooper & Dunham LLP
Gershik Gary J.
Shaw Amanda
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