Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1990-12-14
1995-05-09
Spiegel, Carol A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 792, 436 96, 436 91, 436119, 436537, 422 70, G01N 3353, G01N 3002
Patent
active
054139112
ABSTRACT:
Method and reagents for determining a compound of interest present in a test sample also containing one or more interfering compounds having substantially similar chemical structures, and otherwise analytically indistinguishable from each other, employing a pretreatment reagent capable of selectively modifying the chemical structure of one of the compounds without significantly modifying or altering the chemical structure of the other one of the compounds. The selective modification results in the modified compound having a chemical structure which is substantially dissimilar to the chemical structure of the other one of said compounds wherein the compounds are substantially distinguishable from each other to permit the analytical determination of one or the other of such compounds by immunoassay, high pressure liquid chromatography, and thin layer chromatography techniques, especially for the fluorescent polarization immunoassay determination of tricyclic antidepressant drugs in the presence of phenothiazines.
REFERENCES:
patent: 4668620 (1987-05-01), Armenta et al.
patent: 4810635 (1989-03-01), Ledden et al.
patent: 4820416 (1989-04-01), Chang et al.
patent: 4829012 (1989-05-01), Cambiaso et al.
patent: 4886743 (1989-12-01), Hood et al.
patent: 5216132 (1993-06-01), Basi
Burns et al., "Both Rat and Mouse T Cell Receptors Specific for the Encephalitogenic Determinant of Myelin Basic Protein Use Similar V .alpha. and V .beta. Chain Genes Even Though the Major Histocompatibility Complex and Encephalitogenic Determinants Being Recognized are Different", J. Exp. Med., 169:27-39 (1989).
Urban et al., "Restricted use of T Cell Receptor V Genes in Murine Autoimmune Encephalomyelitis Raises Possibilities for Antibody Therapy", Cell, 54:577-592 (1988).
Lohse et al., "Control of Experimental Autoimmune Encephalomyelitis by T Cells Responding to Activated T Cells", Science, 244:820-822 (1989).
Banerjee et al., "Possible Role of V.sub..beta. T Cell Receptor Genes in Susceptibility to Collagen-Induced Arthritis in Mice", J. Exp. Med., 167:832-839 (1988).
Fowlkes et al., "A Novel Population of T-cell Receptor .alpha..beta.-Bearing Thymocytes Which Predominantly Expresses a Single V.sub..beta. Gene Family", Nature, 329:251-254 (1987).
Shortman et al., "Mouse Strain Differences in Subset Distribution and T Cell Antigen Receptor Expression Among CD4.sup.- CD8.sup.- Thymocytes", Immunol. Cell Biol., 66:423-433 (1988).
Takahama et al., "Phenotype, Ontogeny, and Repertoire of CD4.sup.- CD8.sup.- T Cell Receptor .alpha..beta..sup.+ Thymocytes", J. Immunol., 146:1134-1141 (1991).
Bertness et al., "T-Cell Receptor Gene Rearrangements as Clinical Markers of Human T-Cell Lymphomas", N. Engl. J. Med., 313:534-538 (1985).
Tomai et al., "Superantigenicity of Streptococcal M Protein", J. Exp. Med., 172:359-362 (1990).
Atkin et al., "Stimulation of Mouse Lymphocytes by a Mitogen Derived from Mycoplasma Arthritidis", J. Immunol., 137:1581-1589 (1986).
Cole and Ward, "Mycoplasmas as Arthritogenic Agents", In: The Mycoplasmas, vol. IV, New York, Academic Press, pp. 367-398 (1979).
Cole et al., "Stimulation of Mouse Lymphocytes by a Mitogen Derived From Mycoplasma arthritidis", J. Immunol., 142:4131-4137 (1989).
Chothia et al., "The Outline Structure of the T-Cell .alpha..beta. Receptor", EMBO J., 7:3745-3755 (1988).
Howell et al., "Clonal Infiltrates of Activated V.beta.17+T Cells in Synovial Tissues of Rheumatoid Arthritis Patients", J. Cell Biochem. Suppl., 15A:295 (1991).
Pallard et al., "Evidence for the Effects of a Superantigen in Rheumatoid Arthritis", Science, 253:325-329 (1991).
Towbin et al., "Electrophoretic Transfer of Proteins from Polyacrylamide Gels to Nitrocellulose Sheets: Procedure and Some Applications", Proc. Natl. Acad. Sci. USA, 76:4350-4354 (1979).
Wang et al., "Stimulation and Expansion of a Human T-Cell Subpopulation by a Monoclonal Antibody to T-Cell Receptor Molecule", Hybridoma, 5:719-790 (1986).
Posnett et al., "Inherited Polymorphism of the Human T-Cell Antigen Receptor Detected by a Monoclonal Antibody", Proc. Natl. Acad. Sci. USA, 83:7888-7892 (11986).
Li et al., "Allelic Variations in the Human T Cell Receptor V.beta.6.7 Gene Products", J. Exp. Med., 171:221-230 (1990).
Friedman et al., "Amplification of Altered Self-reactive Cytolytic T Lymphocyte Responses by Cloned, Allospecific Human T.sub.h Cells", J. Clin. Invest., 82:1722-1730 (1988).
Choi et al., "Selective Expansion of T Cells Expressing V.beta.2 in Toxic Shock Syndrome", J. Exp. Med., 172:981-984 (1990).
Fleischer et al., "An Evolutionary Conserved Mechanism of T Cell Activation by Microbial Toxins", J. Immunol., 146:11-17 (1991).
Posnett et al., "A Novel Method for Producing Anti-peptide Antibodies", J. Biol. Chem., 263:1719-1725 (1988).
Chomczynski and Sacchi, "Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate-Phenol-Chloroform Extraction", Anal. Biochem., 162:156-159 (1987).
Concannon et al., "Diversity and Structure of Human T-Cell Receptor .beta.-Chain Variable Region Genes", Proc. Natl. Acad. Sci. USA, 83:6598-6602 (1986).
Kimura et al., "Sequences and Repertoire of the Human T Cell Receptor .alpha. and .beta. Chain Variable Region Genes in Thymocytes", Eur. J. Immunol., 17:375-383 (1987).
Aldrich Chemical Catalog 1986, pp. 283, 1194 and 1196.
Alltech Chromatography Catalog 1988, pp. 58, 258-264.
Chemical Abstract 98 (7):46295.
Chemical Abstract 106(17):31135.
Biosis Abstract 68056243.
Adamczyk Maciej
Fishpaugh Jeffrey R.
Harrington Charles A.
Hartter Daryl E.
Hruska Robert E.
Abbott Laboratories
Spiegel Carol A.
Steele Gregory W.
LandOfFree
Determination of tricyclic antidepressant drugs in the presence does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Determination of tricyclic antidepressant drugs in the presence , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Determination of tricyclic antidepressant drugs in the presence will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1704793